D
Diane P. Genereux
Researcher at Broad Institute
Publications - 37
Citations - 1731
Diane P. Genereux is an academic researcher from Broad Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 27 publications receiving 947 citations. Previous affiliations of Diane P. Genereux include University of Washington & Emory University.
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Journal ArticleDOI
Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.
Joana Damas,Graham M. Hughes,Kathleen C. Keough,Corrie A. Painter,Nicole S. Persky,Marco Corbo,Michael Hiller,Klaus-Peter Koepfli,Andreas R. Pfenning,Huabin Zhao,Huabin Zhao,Diane P. Genereux,Ross Swofford,Katherine S. Pollard,Oliver A. Ryder,Martin T. Nweeia,Martin T. Nweeia,Martin T. Nweeia,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Emma C. Teeling,Elinor K. Karlsson,Elinor K. Karlsson,Harris A. Lewin +23 more
TL;DR: A large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins are identified to assist the identification of intermediate hosts for Sars-Cov-2 and hence reduce the opportunity for a future outbreak of COVID-19.
Journal ArticleDOI
Progressive Cactus is a multiple-genome aligner for the thousand-genome era
Joel Armstrong,Glenn Hickey,Mark Diekhans,Ian T. Fiddes,Adam M. Novak,Alden Deran,Qi Fang,Duo Xie,Shaohong Feng,Josefin Stiller,Diane P. Genereux,Jeremy A. Johnson,Voichita D. Marinescu,Jessica Alföldi,Robert S. Harris,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,David Haussler,David Haussler,Elinor K. Karlsson,Elinor K. Karlsson,Erich D. Jarvis,Erich D. Jarvis,Guojie Zhang,Benedict Paten +24 more
TL;DR: Progressive Cactus as discussed by the authors is a reference-free multiple genome alignment program that enables the alignment of tens to thousands of large vertebrate genomes while maintaining high alignment quality, which is the largest multiple vertebrate genome alignment created so far.
Journal ArticleDOI
A comparative genomics multitool for scientific discovery and conservation
Diane P. Genereux,Aitor Serres,Joel Armstrong,Jeremy Johnson,Voichita D. Marinescu,Eva Murén,David Juan,Gill Bejerano,Nicholas R. Casewell,Leona G. Chemnick,Joana Damas,Federica Di Palma,Mark Diekhans,Ian T. Fiddes,Manuel Garber,Vadim N. Gladyshev,Linda Goodman,Wilfried Haerty,Marlys L. Houck,Robert Hubley,Teemu Kivioja,Klaus-Peter Koepfli,Lukas F. K. Kuderna,Eric S. Lander,Jennifer R. S. Meadows,William J. Murphy,Will Nash,Hyun Ji Noh,Martin T. Nweeia,Andreas R. Pfenning,Katherine S. Pollard,David A. Ray,Beth Shapiro,Arian F.A. Smit,Mark S. Springer,Cynthia C. Steiner,Ross Swofford,Jussi Taipale,Emma C. Teeling,Jason Turner-Maier,Jessica Alföldi,Bruce W. Birren,Oliver A. Ryder,Harris A. Lewin,Benedict Paten,Tomas Marques-Bonet,Kerstin Lindblad-Toh,Elinor K. Karlsson +47 more
TL;DR: It is found that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes.
Journal ArticleDOI
Errors in the bisulfite conversion of DNA: modulating inappropriate- and failed-conversion frequencies
TL;DR: Molecule encoding was used to obtain validated, individual-molecule data on failed- and inappropriate-conversion frequencies for LowMT and HighMT treatments of both single-stranded and hairpin-linked oligonucleotides, finding that the HighMT treatment is preferable because it yields greater homogeneity among sites and among molecules in conversion rates, and thus yields more reliable data.
Journal ArticleDOI
Transient exposure to low levels of insecticide affects metabolic networks of honeybee larvae
K. Derecka,Martin J. Blythe,Sunir Malla,Diane P. Genereux,Alessandro Guffanti,Paolo Pavan,Anna Moles,Charles J. P. Snart,Thomas Ryder,Catharine A. Ortori,David A. Barrett,Eugene Schuster,Reinhard Stöger +12 more
TL;DR: The multifaceted, physiological response described here may be of importance to the general understanding of pollinator health, as muscles work at high glycolytic rates and flight performance could be impacted should low levels of this evolutionarily novel stressor likewise induce downregulation of energy metabolising genes in adult pollinators.