D
Dietmar Herndler-Brandstetter
Researcher at Yale University
Publications - 54
Citations - 3665
Dietmar Herndler-Brandstetter is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 26, co-authored 49 publications receiving 3168 citations. Previous affiliations of Dietmar Herndler-Brandstetter include Austrian Academy of Sciences & University of Innsbruck.
Papers
More filters
Journal ArticleDOI
Biology of immune responses to vaccines in elderly persons.
Birgit Weinberger,Dietmar Herndler-Brandstetter,Angelika Schwanninger,Daniela Weiskopf,Beatrix Grubeck-Loebenstein +4 more
TL;DR: Improved vaccination strategies, new adjuvants, and new vaccines that specifically target the aged immune system will help to overcome the limitations of immunosenescence and ensure a better protection of the vulnerable elderly population.
Journal ArticleDOI
miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging
Matthias Hackl,S. E. Brunner,Klaus Fortschegger,Carina Schreiner,Lucia Micutkova,Christoph Mück,Gerhard Laschober,Günter Lepperdinger,Natalie Sampson,Peter Berger,Dietmar Herndler-Brandstetter,Matthias Wieser,Harald Kühnel,Alois Strasser,Mark Rinnerthaler,Michael Breitenbach,Michael Mildner,Leopold Eckhart,Erwin Tschachler,Andrea Trost,Johann W. Bauer,Christine Papak,Zlatko Trajanoski,Marcel Scheideler,Regina Grillari-Voglauer,Beatrix Grubeck-Loebenstein,Pidder Jansen-Dürr,Johannes Grillari +27 more
TL;DR: Decrease in these miRNAs correlated with increased transcript levels of some established target genes, especially the cdk inhibitor p21/CDKN1A, establish mi RNAs as novel markers of cell aging in humans.
Journal ArticleDOI
Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8 T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons
Giovanni Almanzar,Susanne Schwaiger,Brigitte Jenewein,Michael Keller,Dietmar Herndler-Brandstetter,Reinhard Würzner,Diether Schönitzer,Beatrix Grubeck-Loebenstein +7 more
TL;DR: It is demonstrated that aging as well as CMV infection lead to a decrease in the size of the naïve and the early memory T-cell pool but to an increase in the number of CD8+ effector T cells, which produce gamma interferon but lack substantial growth potential.
Journal ArticleDOI
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Dietmar Herndler-Brandstetter,Harumichi Ishigame,Ryo Shinnakasu,Valerie Plajer,Carmen Stecher,Jun Zhao,Melanie Lietzenmayer,Lina Kroehling,Akiko Takumi,Kohei Kometani,Takeshi Inoue,Yuval Kluger,Susan M. Kaech,Tomohiro Kurosaki,Takaharu Okada,Richard A. Flavell +15 more
TL;DR: It is demonstrated that developmental plasticity of KLRG1+ effector CD8+ T cells is important in promoting functionally versatile memory cells and long‐term protective immunity and drives functional diversity within memory T cell lineages and promotes enhanced anti‐influenza and anti‐tumor immunity.
Journal ArticleDOI
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Nan Guo Ring,Nan Guo Ring,Dietmar Herndler-Brandstetter,Kipp Weiskopf,Liang Shan,Jens Peter Volkmer,Benson M. George,Melanie Lietzenmayer,Mckenna Kelly Marie,Tejaswitha J. Naik,Aaron McCarty,Yunjiang Zheng,Aaron M. Ring,Richard A. Flavell,Richard A. Flavell,Irving L. Weissman +15 more
TL;DR: An anti-human SIRPα antibody, KWAR23, is developed, which in combination with tumor-opsonizing antibodies, greatly augmented neutrophil and macrophage antitumor activity in vitro and in vivo and may represent a promising candidate for combination therapies.