Ryo Shinnakasu

TL;DR: It is found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4+ T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage, resulting in the post-thymic termination of the helpers T cell program and the functional differentiation of distinct MHC class II–restrictedCD4+ cytotoxic T lymphocytes.

TL;DR: An instructive model is proposed in which weak help from T cells maintains relatively high expression of Bach2, which predisposes GC cells to enter the memory pool.

TL;DR: It is demonstrated that developmental plasticity of KLRG1+ effector CD8+ T cells is important in promoting functionally versatile memory cells and long‐term protective immunity and drives functional diversity within memory T cell lineages and promotes enhanced anti‐influenza and anti‐tumor immunity.

TL;DR: The results suggest that repression of the Bach2 transcription factor, which results from antigen experience, contributes to predisposition of IgG1 memory B cells to differentiate into plasma cells.

TL;DR: It is demonstrated that T cell receptor-mediated activation of the Ras-ERK MAPK cascade stabilizes GATA3 protein in developing Th2 cells through the inhibition of the ubiquitin-proteasome pathway.