Dirk Seegert

TL;DR: A significant difference in association of the 113A DLG5 variant with Crohn disease is found in affected individuals carrying the risk- associated CARD15 alleles versus those carrying non-risk-associated CARD 15 alleles, suggestive of a complex pattern of gene-gene interaction betweenDLG5 and CARD15, reflecting the complex nature of polygenic diseases.

TL;DR: A preliminary investigation of 5 patients with CDI shows that transfer of sterile filtrates from donor stool (FFT), rather than fecal microbiota, can be sufficient to restore normal stool habits and eliminate symptoms.

TL;DR: A systematic three-stage SNP scan of 16.4 Mb on chromosome 6p21 in as many as 947 independent cases of familial and sporadic sarcoidosis and found that a 15-kb segment of the gene butyrophilin-like 2 (BTNL2) was associated with the disease.

TL;DR: TNF-α(/IFN-γ) treatment up-regulates the expression of the NOD2 gene in intestinal epithelial cells and subsequently increases their LPS susceptibility.

TL;DR: P38α signaling is involved in the pathophysiology of IBD, and ELISA screening of the supernatants of Crohn’s disease mucosal biopsy cultures showed that incubation with the p38 inhibitor SB 203580 significantly reduced secretion of TNF-α.