D
Dmitri Loukinov
Researcher at National Institutes of Health
Publications - 41
Citations - 4176
Dmitri Loukinov is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CTCF & DNA methylation. The author has an hindex of 27, co-authored 39 publications receiving 3824 citations. Previous affiliations of Dmitri Loukinov include Government of the United States of America.
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Journal ArticleDOI
Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome
Tae Hoon Kim,Ziedulla Abdullaev,Andrew D. Smith,Keith A. Ching,Dmitri Loukinov,Roland Green,Michael Q. Zhang,Victor V. Lobanenkov,Bing Ren +8 more
TL;DR: 13,804 CTCF-binding sites in potential insulators of the human genome are described, discovered experimentally in primary human fibroblasts and fit to a consensus motif highly conserved and suitable for predicting possible insulators driven by CTCf in other vertebrate genomes.
Journal ArticleDOI
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
Chandrasekhar Kanduri,Vinod Pant,Dmitri Loukinov,Elena M. Pugacheva,Chen Feng Qi,Alan P. Wolffe,Rolf Ohlsson,Victor V. Lobanenkov +7 more
TL;DR: Observations suggest that molecular mechanisms of genomic imprinting may use an unusual ability of CTCF to interact with a diverse spectrum of variant target sites, some of which include CpGs that are responsible for methylation-sensitive C TCF binding in vitro and in vivo.
Journal ArticleDOI
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
Dmitri Loukinov,Elena M. Pugacheva,Sergei Vatolin,Svetlana Pack,Hanlim Moon,Igor Chernukhin,Poonam Mannan,Erik G. Larsson,Chandrasekhar Kanduri,Alexander A. Vostrov,Hengmi Cui,Emily L. Niemitz,John E.J. Rasko,Malathi K. Kistler,Joseph J. Breen,Zhengping Zhuang,Wolfgang W. Quitschke,Rainer Renkawitz,Elena Klenova,Andrew P. Feinberg,Rolf Ohlsson,Herbert C. Morse,Victor V. Lobanenkov +22 more
TL;DR: It is shown here that erasure of methylation marks during male germ-line development is associated with dramatic up- regulation of BORIS and down-regulation of CTCF expression, and BORis is a candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line.
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Conditional Expression of the CTCF-Paralogous Transcriptional Factor BORIS in Normal Cells Results in Demethylation and Derepression of MAGE-A1 and Reactivation of Other Cancer-Testis Genes
Sergei Vatolin,Ziedulla Abdullaev,Svetlana Pack,Patrick T. Flanagan,Mary C. Custer,Dmitri Loukinov,Elena M. Pugacheva,Julie A. Hong,Herbert C. Morse,David S. Schrump,John I. Risinger,J. Carl Barrett,Victor V. Lobanenkov +12 more
TL;DR: It is suggested that BORIS is likely tethering epigenetic machinery to a novel class of CTCF/BORIS 11ZF target sequences that mediate induction of cancer-testis genes.
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Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells.
Julie A. Hong,Yang Kang,Ziedulla Abdullaev,Patrick T. Flanagan,Svetlana Pack,Maria R. Fischette,Mina T. Adnani,Dmitri Loukinov,Sergei Vatolin,John I. Risinger,Mary C. Custer,G. Aaron Chen,Ming Zhao,Dao M. Nguyen,J. Carl Barrett,Victor V. Lobanenkov,David S. Schrump +16 more
TL;DR: Rec reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter mediates epigenetic regulation of this CT gene in lung cancer cells, and suggest that induction of BORis may be a novel strategy to augment immunogenicity of pulmonary carcinomas.