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E. Ashley Moseman
Researcher at Duke University
Publications - 32
Citations - 5943
E. Ashley Moseman is an academic researcher from Duke University. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 22, co-authored 27 publications receiving 5015 citations. Previous affiliations of E. Ashley Moseman include University of Minnesota & Harvard University.
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Journal ArticleDOI
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Tobias Junt,E. Ashley Moseman,Matteo Iannacone,Steffen Massberg,Philipp A. Lang,Marianne Boes,Katja Fink,Sarah E. Henrickson,Dmitry M. Shayakhmetov,Nelson C. Di Paolo,Nico van Rooijen,Thorsten R. Mempel,Sean P. J. Whelan,Ulrich H. von Andrian +13 more
TL;DR: Findings indicate that CD169+ macrophages have a dual physiological function that acts as innate ‘flypaper’ by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph–tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses.
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Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral Tissues
Steffen Massberg,Patrick Schaerli,Irina Knezevic-Maramica,Maria Köllnberger,Noah J. Tubo,E. Ashley Moseman,Ines V. Huff,Tobias Junt,Amy J. Wagers,Amy J. Wagers,Irina B. Mazo,Ulrich H. von Andrian +11 more
TL;DR: It is shown that mouse thoracic duct lymph contains HSPCs that possess short- and long-term multilineage reconstitution capacity and can foster the local production of tissue-resident innate immune cells under both steady-state conditions and in response to inflammatory signals.
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Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells
E. Ashley Moseman,Xueqing Liang,Amanda J. Dawson,Angela Panoskaltsis-Mortari,Arthur M. Krieg,Yong-Jun Liu,Bruce R. Blazar,Wei Chen +7 more
TL;DR: It is demonstrated that TLR9 stimulation can promote PDC-mediated generation of CD4+CD25+ Treg cells and suggests PDCs may play an important role in the maintenance of immunological tolerance.
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Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses
Silke Paust,Silke Paust,Harvinder S. Gill,Harvinder S. Gill,Bao-Zhong Wang,Michael P Flynn,E. Ashley Moseman,Balimkiz Senman,Marian Szczepanik,Marian Szczepanik,Amalio Telenti,Amalio Telenti,Philip W. Askenase,Richard W. Compans,Ulrich H. von Andrian +14 more
TL;DR: Hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell–expressed CXCR6, a chemokine receptor on NK cells that was required for the persistence of memory NK cells but not for antigen recognition.
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The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis
Carmen Gerlach,E. Ashley Moseman,Scott Loughhead,David Alvarez,Anthonie J. Zwijnenburg,Lisette Waanders,Rohit Garg,Juan Carlos de la Torre,Ulrich H. von Andrian,Ulrich H. von Andrian +9 more
TL;DR: A subset of CX3CR1int Tmem cells present unique phenotypic, homeostatic, and migratory properties, and it is proposed that tpm cells are chiefly responsible for the global surveillance of non-lymphoid tissues.