scispace - formally typeset
Open AccessJournal ArticleDOI

The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis

Carmen Gerlach, +9 more
- 20 Dec 2016 - 
- Vol. 45, Iss: 6, pp 1270-1284
Reads0
Chats0
TLDR
A subset of CX3CR1int Tmem cells present unique phenotypic, homeostatic, and migratory properties, and it is proposed that tpm cells are chiefly responsible for the global surveillance of non-lymphoid tissues.
About: 
This article is published in Immunity.The article was published on 2016-12-20 and is currently open access. It has received 372 citations till now. The article focuses on the topics: Cytotoxic T cell & Chemokine receptor.

read more

Citations
More filters
Journal ArticleDOI

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.

Guo Xinyi, +18 more
- 25 Jun 2018 - 
TL;DR: Deep single-cell RNA sequencing of tumor-infiltrating T cells in non-small-cell lung cancer identifies features associated with functional states and clinical outcome and provides a new approach for patient stratification.
Journal ArticleDOI

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Andrea Cossarizza, +462 more
- 01 Oct 2019 - 
TL;DR: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community providing the theory and key practical aspects offlow cytometry enabling immunologists to avoid the common errors that often undermine immunological data.
Journal ArticleDOI

A guide to chemokines and their receptors.

Catherine E. Hughes, +1 more
- 01 Aug 2018 - 
TL;DR: This guide gives a broad overview of the chemokines and chemokine receptor families; summarizes the complex physical interactions that occur in theChemokine network; and, using specific examples, discusses general principles of Chemokine function, focusing particularly on their ability to direct leukocyte migration.
Journal ArticleDOI

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells.

Sema Kurtulus, +14 more
- 15 Jan 2019 - 
TL;DR: The dynamics of the effector response of CD8+ tumor‐infiltrating lymphocytes (TILs) after checkpoint blockade therapy was examined, showing a shift from naive‐like to memory‐precursor‐ and effector‐like subsets within PD‐1−CD8+ T cells in tumors.
Journal ArticleDOI

Tissue-Resident T Cells and Other Resident Leukocytes.

David Masopust, +1 more
- 06 Feb 2019 - 
TL;DR: CD8+ and CD4+ Trm ontogeny, maintenance, function, and distribution within lymphoid and nonlymphoid tissues and strategies for their study are reviewed.
References
More filters
Journal ArticleDOI

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

Federica Sallusto, +4 more
- 14 Oct 1999 - 
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal Article

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

Johannes Gerdes, +5 more
- 01 Oct 1984 - 
TL;DR: The data suggest that the early stages of mitogen stimulation represent initial sequences of proliferation and not parts of the cell cycle, and immunostaining with monoclonal antibody Ki-67 provides a reliable means of rapidly evaluating the growth fraction of normal and neoplastic human cell populations.
Journal ArticleDOI

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Frederic Geissmann, +2 more
- 01 Jul 2003 - 
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
Journal ArticleDOI

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

Federica Sallusto, +2 more
- 19 Mar 2004 - 
TL;DR: This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.
Journal ArticleDOI

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.

Steffen Jung, +6 more
- 01 Jun 2000 - 
TL;DR: Defying anticipated FKN functions, absence of CX3CR1 interferes neither with monocyte extravasation in a peritonitis model nor with DC migration and differentiation in response to microbial antigens or contact sensitizers.
Related Papers (5)

The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.

Laura K. Mackay, +14 more
- 01 Dec 2013 - 

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

Federica Sallusto, +4 more
- 14 Oct 1999 - 

Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.

Nikhil S. Joshi, +7 more
- 24 Aug 2007 - 

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.

Laura K. Mackay, +35 more
- 22 Apr 2016 - 

Tissue-resident memory T cells: local specialists in immune defence

Scott N. Mueller, +3 more
- 01 Feb 2016 -