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Mercedes F. Paredes
Researcher at University of California, San Francisco
Publications - 46
Citations - 3747
Mercedes F. Paredes is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Neurogenesis & Interneuron. The author has an hindex of 21, co-authored 35 publications receiving 2770 citations. Previous affiliations of Mercedes F. Paredes include Harvard University.
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Journal ArticleDOI
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Shawn F. Sorrells,Mercedes F. Paredes,Arantxa Cebrián-Silla,Kadellyn Sandoval,Dashi Qi,Kevin W. Kelley,David James,Simone Mayer,Julia W. Chang,Kurtis I. Auguste,Edward F. Chang,Antonio Gutierrez,Arnold R. Kriegstein,Gary W. Mathern,Michael C. Oldham,Eric J. Huang,José Manuel García-Verdugo,Zhengang Yang,Arturo Alvarez-Buylla +18 more
TL;DR: It is shown that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development, and that neurogenesis in the dentate gyrus does not continue, or is extremely rare, in adult humans.
Journal ArticleDOI
Intrinsically determined cell death of developing cortical interneurons
Derek G. Southwell,Mercedes F. Paredes,Rui P. Galvao,Rui P. Galvao,Dan Jones,Robert C. Froemke,Robert C. Froemke,Joy Y. Sebe,Clara Alfaro-Cervello,Clara Alfaro-Cervello,Yunshuo Tang,José Manuel García-Verdugo,John L.R. Rubenstein,Scott C. Baraban,Arturo Alvarez-Buylla +14 more
TL;DR: The findings indicate that interneuron cell death is determined intrinsically, either cell-autonomously or through a population-autonomous competition for survival signals derived from other interneurons.
Journal ArticleDOI
Extensive migration of young neurons into the infant human frontal lobe
Mercedes F. Paredes,David James,Sara Gil-Perotin,Sara Gil-Perotin,Hosung Kim,Jennifer A. Cotter,Carissa Ng,Kadellyn Sandoval,David H. Rowitch,David H. Rowitch,Duan Xu,Patrick S. McQuillen,José Manuel García-Verdugo,Eric J. Huang,Arturo Alvarez-Buylla +14 more
TL;DR: Using high-resolution magnetic resonance imaging, histology, and time-lapse confocal microscopy, the migration of many young inhibitory interneurons around the dorsal anterior walls of the lateral ventricle and into multiple cortical regions of the human frontal cortex was observed.
Journal ArticleDOI
Encephalitis and AMPA receptor antibodies Novel findings in a case series of 22 patients
Romana Höftberger,Agnes van Sonderen,Frank Leypoldt,David J. Houghton,Michael D. Geschwind,Jeffrey Gelfand,Mercedes F. Paredes,Lidia Sabater,Albert Saiz,Maarten J. Titulaer,Francesc Graus,Josep Dalmau +11 more
TL;DR: Anti-AMPAR encephalitis usually manifests as LE, can present with other symptoms or psychosis, and is paraneoplastic in 64% of cases, but most patients have partial recovery.
Journal ArticleDOI
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
Omer Ali Bayraktar,Omer Ali Bayraktar,Omer Ali Bayraktar,Theresa Bartels,Staffan Holmqvist,Vitalii Kleshchevnikov,Araks Martirosyan,Damon Polioudakis,Damon Polioudakis,Lucile Ben Haim,Adam Young,Mykhailo Y. Batiuk,Kirti Prakash,Alexander Brown,Kenny Roberts,Mercedes F. Paredes,Riki Kawaguchi,John H. Stockley,Khalida Sabeur,Khalida Sabeur,Sandra Chang,Sandra Chang,Eric J. Huang,Peter J. Hutchinson,Erik M. Ullian,Martin Hemberg,Giovanni Coppola,Matthew Holt,Daniel H. Geschwind,Daniel H. Geschwind,David H. Rowitch,David H. Rowitch +31 more
TL;DR: The present study developed a high-content pipeline, the large-area spatial transcriptomic (LaST) map, which can quantify single-cell gene expression in situ, and reveals astrocyte heterogeneity across layers of the mammalian cerebral cortex.