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Edward Lau
Researcher at Anschutz Medical Campus
Publications - 73
Citations - 1817
Edward Lau is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Proteome & Mitochondrion. The author has an hindex of 26, co-authored 67 publications receiving 1433 citations. Previous affiliations of Edward Lau include Stanford University & National Institutes of Health.
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Journal ArticleDOI
Metabolic Labeling Reveals Proteome Dynamics of Mouse Mitochondria
Tae-Young Kim,Ding Wang,Allen K. Kim,Edward Lau,Amanda J. Lin,David A. Liem,Jun Zhang,Nobel C. Zong,Maggie P.Y. Lam,Peipei Ping +9 more
TL;DR: The proteomics platform demonstrates the first large-scale analysis of mitochondrial protein turnover rates in vivo, with potential applications in translational research.
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Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Jae Cheol Lee,Vittavat Termglinchan,Vittavat Termglinchan,Sebastian Diecke,Ilanit Itzhaki,Ilanit Itzhaki,Chi Keung Lam,Chi Keung Lam,Priyanka Garg,Priyanka Garg,Edward Lau,Edward Lau,Matthew Greenhaw,Timon Seeger,Timon Seeger,Haodi Wu,Haodi Wu,Joe Z. Zhang,Joe Z. Zhang,Xingqi Chen,Isaac Perea Gil,Isaac Perea Gil,Mohamed Ameen,Mohamed Ameen,Karim Sallam,Karim Sallam,June-Wha Rhee,June-Wha Rhee,Jared M. Churko,Jared M. Churko,Rinkal Chaudhary,Rinkal Chaudhary,Tony Chour,Tony Chour,Paul J. Wang,Michael Snyder,Michael Snyder,Howard Y. Chang,Howard Y. Chang,Ioannis Karakikes,Ioannis Karakikes,Joseph C. Wu,Joseph C. Wu +42 more
TL;DR: A disease model using cardiomyocytes derived from induced pluripotent stem cells of patients with mutated LMNA-related dilated cardiopathy reveals that the abnormal activation of the PDGF pathway is associated with the arrhythmic phenotypes of patients.
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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
Maggie P.Y. Lam,Ding Wang,Edward Lau,David A. Liem,Allen K. Kim,Dominic C. M. Ng,Xiangbo Liang,Brian J. Bleakley,Chenguang Liu,Jason D. Tabaraki,Martin Cadeiras,Yibin Wang,Mario C. Deng,Peipei Ping +13 more
TL;DR: A workflow that integrates deuterium oxide labeling, high-resolution mass spectrometry (MS), and custom computational methods to systematically interrogate in vivo protein turnover is developed and should be widely applicable to large-scale biomolecular investigations of human disease mechanisms with a temporal perspective.
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A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay
Timon Seeger,Rajani Shrestha,Chi Keung Lam,Caressa Chen,Wesley L. McKeithan,Edward Lau,Alexa Wnorowski,George McMullen,Matthew Greenhaw,Jae Cheol Lee,Angelos Oikonomopoulos,Soah Lee,Huaxiao Yang,Mark Mercola,Matthew T. Wheeler,Euan A. Ashley,Fan Yang,Ioannis Karakikes,Joseph C. Wu +18 more
TL;DR: iPSC-CMs carrying MYBPC3 PTC mutations displayed aberrant calcium signaling and molecular dysregulations in the absence of significant haploinsufficiency of MYB PC3 protein, providing the first evidence of the direct connection between the chronically activated nonsense-mediated decay pathway and HCM disease development.
Journal ArticleDOI
A large dataset of protein dynamics in the mammalian heart proteome.
Edward Lau,Quan Cao,Quan Cao,Dominic C. M. Ng,Brian J. Bleakley,T. Umut Dincer,Brian M. Bot,Brian M. Bot,Ding Wang,David A. Liem,Maggie P.Y. Lam,Junbo Ge,Peipei Ping +12 more
TL;DR: A comprehensive dataset of the in vivo half-life of 3,228 and the expression of 8,064 cardiac proteins, quantified under healthy and hypertrophic conditions across six mouse genetic strains commonly employed in biomedical research is reported.