H
Huaxiao Yang
Researcher at University of North Texas
Publications - 42
Citations - 1024
Huaxiao Yang is an academic researcher from University of North Texas. The author has contributed to research in topics: Stem cell & Induced pluripotent stem cell. The author has an hindex of 17, co-authored 36 publications receiving 687 citations. Previous affiliations of Huaxiao Yang include Stanford University & Fudan University.
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Journal ArticleDOI
Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling.
Oscar J. Abilez,Evangeline Tzatzalos,Huaxiao Yang,Ming-Tao Zhao,Gwanghyun Jung,Alexander M. Zöllner,Malte Tiburcy,Johannes Riegler,Elena Matsa,Praveen K. Shukla,Yan Zhuge,Tony Chour,Vincent C. Chen,Paul W. Burridge,Ioannis Karakikes,Ellen Kuhl,Daniel Bernstein,Larry A. Couture,Joseph D. Gold,Wolfram H. Zimmermann,Joseph C. Wu +20 more
TL;DR: The effects of varying passive stretch on engineered heart muscle (EHM) structural and functional maturation are tested and how to optimize cell alignment and calcium dynamics within EHMs is shown, which enables future scale‐up productions for clinical use in cardiovascular tissue engineering.
Journal ArticleDOI
An in Vivo miRNA Delivery System for Restoring Infarcted Myocardium
Huaxiao Yang,Xulei Qin,Huiyuan Wang,Xin Zhao,Yonggang Liu,Hung-Ta Wo,Chun Liu,Masataka Nishiga,Haodong Chen,Jing Ge,Nazish Sayed,Oscar J. Abilez,Dan Ding,Sarah C. Heilshorn,Kai Li,Kai Li +15 more
TL;DR: An in vivo delivery system using polymeric nanoparticles to carry miRNA (miNPs) for localized delivery within a shear-thinning injectable hydrogel to restore injured myocardium efficiently and safely is established.
Journal ArticleDOI
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients
Haodi Wu,Huaxiao Yang,June-Wha Rhee,Joe Z. Zhang,Chi Keung Lam,Karim Sallam,Alex C.Y. Chang,Ning Ma,Jae Cheol Lee,Hao Zhang,Helen M. Blau,Donald M. Bers,Joseph C. Wu +12 more
TL;DR: This study recapitulated DD in HCM at the single-cell level, and revealed novel cellular mechanisms and potential therapeutic targets of DD using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Journal ArticleDOI
A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay
Timon Seeger,Rajani Shrestha,Chi Keung Lam,Caressa Chen,Wesley L. McKeithan,Edward Lau,Alexa Wnorowski,George McMullen,Matthew Greenhaw,Jae Cheol Lee,Angelos Oikonomopoulos,Soah Lee,Huaxiao Yang,Mark Mercola,Matthew T. Wheeler,Euan A. Ashley,Fan Yang,Ioannis Karakikes,Joseph C. Wu +18 more
TL;DR: iPSC-CMs carrying MYBPC3 PTC mutations displayed aberrant calcium signaling and molecular dysregulations in the absence of significant haploinsufficiency of MYB PC3 protein, providing the first evidence of the direct connection between the chronically activated nonsense-mediated decay pathway and HCM disease development.
Journal ArticleDOI
Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs
Ming-Tao Zhao,Haodong Chen,Qing Liu,Ning-Yi Shao,Nazish Sayed,Hung Ta Wo,Joe Z. Zhang,Sang-Ging Ong,Chun Liu,Youngkyun Kim,Huaxiao Yang,Tony Chour,Hong Ma,Nuria Marti Gutierrez,Ioannis Karakikes,Shoukhrat Mitalipov,Michael Snyder,Joseph C. Wu +17 more
TL;DR: It is concluded that human iPSCs are capable of replacing SCNT for generating differentiated cells for drug testing and disease modeling and can replace nt-ESCs as alternatives for generating patient-specific differentiation cells for disease modeled and preclinical drug testing.