M
Matthew Greenhaw
Researcher at Stanford University
Publications - 3
Citations - 369
Matthew Greenhaw is an academic researcher from Stanford University. The author has contributed to research in topics: Mutation (genetic algorithm) & Platelet-derived growth factor receptor. The author has an hindex of 3, co-authored 3 publications receiving 163 citations. Previous affiliations of Matthew Greenhaw include Cardiovascular Institute of the South.
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Journal ArticleDOI
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
Dries A. M. Feyen,Dries A. M. Feyen,Wesley L. McKeithan,Wesley L. McKeithan,Wesley L. McKeithan,Arne A. N. Bruyneel,Sean Spiering,Sean Spiering,Larissa Hörmann,Bärbel M. Ulmer,Hui Zhang,Francesca Briganti,Michaela Schweizer,Bence Hegyi,Zhandi Liao,Risto Pekka Pölönen,Kenneth S. Ginsburg,Chi Keung Lam,Ricardo Serrano,Christine Wahlquist,Christine Wahlquist,Christine Wahlquist,Alexander Kreymerman,Michelle Vu,Prashila L Amatya,Charlotta Sophie Behrens,Sara Ranjbarvaziri,Renee G.C. Maas,Renee G.C. Maas,Matthew Greenhaw,Daniel Bernstein,Joseph C. Wu,Donald M. Bers,Thomas Eschenhagen,Christian M. Metallo,Mark Mercola,Mark Mercola,Mark Mercola +37 more
TL;DR: The maturation media designed to provide oxidative substrates adapted to the metabolic needs of human iPSC (hiPSC)-CMs should increase the fidelity of hiPSC-CMs as disease models.
Journal ArticleDOI
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Jae Cheol Lee,Vittavat Termglinchan,Vittavat Termglinchan,Sebastian Diecke,Ilanit Itzhaki,Ilanit Itzhaki,Chi Keung Lam,Chi Keung Lam,Priyanka Garg,Priyanka Garg,Edward Lau,Edward Lau,Matthew Greenhaw,Timon Seeger,Timon Seeger,Haodi Wu,Haodi Wu,Joe Z. Zhang,Joe Z. Zhang,Xingqi Chen,Isaac Perea Gil,Isaac Perea Gil,Mohamed Ameen,Mohamed Ameen,Karim Sallam,Karim Sallam,June-Wha Rhee,June-Wha Rhee,Jared M. Churko,Jared M. Churko,Rinkal Chaudhary,Rinkal Chaudhary,Tony Chour,Tony Chour,Paul J. Wang,Michael Snyder,Michael Snyder,Howard Y. Chang,Howard Y. Chang,Ioannis Karakikes,Ioannis Karakikes,Joseph C. Wu,Joseph C. Wu +42 more
TL;DR: A disease model using cardiomyocytes derived from induced pluripotent stem cells of patients with mutated LMNA-related dilated cardiopathy reveals that the abnormal activation of the PDGF pathway is associated with the arrhythmic phenotypes of patients.
Journal ArticleDOI
A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay
Timon Seeger,Rajani Shrestha,Chi Keung Lam,Caressa Chen,Wesley L. McKeithan,Edward Lau,Alexa Wnorowski,George McMullen,Matthew Greenhaw,Jae Cheol Lee,Angelos Oikonomopoulos,Soah Lee,Huaxiao Yang,Mark Mercola,Matthew T. Wheeler,Euan A. Ashley,Fan Yang,Ioannis Karakikes,Joseph C. Wu +18 more
TL;DR: iPSC-CMs carrying MYBPC3 PTC mutations displayed aberrant calcium signaling and molecular dysregulations in the absence of significant haploinsufficiency of MYB PC3 protein, providing the first evidence of the direct connection between the chronically activated nonsense-mediated decay pathway and HCM disease development.