E
Ee Ming Wong
Researcher at Monash University, Clayton campus
Publications - 58
Citations - 1701
Ee Ming Wong is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: DNA methylation & Cancer. The author has an hindex of 19, co-authored 53 publications receiving 1297 citations. Previous affiliations of Ee Ming Wong include Peter MacCallum Cancer Centre & University of Melbourne.
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Journal ArticleDOI
Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Ee Ming Wong,Melissa C. Southey,Stephen B. Fox,Stephen B. Fox,Melissa A. Brown,James G. Dowty,Mark A. Jenkins,Graham G. Giles,John L. Hopper,Alexander Dobrovic,Alexander Dobrovic +10 more
TL;DR: Women carrying germline mutations in BRCA1 are at a substantially elevated risk of breast cancer and their tumors typically have distinctive morphologic features, which raises the possibility of chemoprevention or other intervention to diminish the risk of developing breast cancer in these women.
Journal ArticleDOI
BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype
Cameron Snell,Michael Krypuy,Ee Ming Wong,Ee Ming Wong,M.B. Loughrey,Alexander Dobrovic,Alexander Dobrovic +6 more
TL;DR: It is demonstrated that in some cases of breast cancer, low-level promoter methylation of BRCA1 occurs in normal tissues of the body and is associated with the development of B RCA1-like breast cancer.
Journal ArticleDOI
DNA methylation-based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies
Pierre Antoine Dugué,Pierre Antoine Dugué,Julie K. Bassett,Jihoon E. Joo,Chol-Hee Jung,Ee Ming Wong,Margarita Moreno-Betancur,Margarita Moreno-Betancur,Daniel F. Schmidt,Enes Makalic,Shuai Li,Gianluca Severi,Allison M. Hodge,Allison M. Hodge,Daniel D. Buchanan,Daniel D. Buchanan,Dallas R. English,Dallas R. English,John L. Hopper,Melissa C. Southey,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Roger L. Milne,Roger L. Milne +24 more
TL;DR: Epigenetic aging was associated with increased cancer risk, ranging from 4% to 9% per five‐year age acceleration for the 5 measures considered, with no evidence of heterogeneity by cancer site.
Journal ArticleDOI
DNA Methylation Changes Measured in Pre-Diagnostic Peripheral Blood Samples Are Associated With Smoking and Lung Cancer Risk
Laura Baglietto,Erica Ponzi,Philip C Haycock,Allison M. Hodge,Manuela Bianca Assumma,Chol-Hee Jung,Jessica Chung,Francesca Fasanelli,Florence Guida,Gianluca Campanella,Marc Chadeau-Hyam,Kjell Grankvist,Mikael Johansson,Ugo Ala,Paolo Provero,Paolo Provero,Ee Ming Wong,Jihoon E. Joo,Dallas R. English,Nabila Kazmi,Eiliv Lund,Christian Faltus,Rudolf Kaaks,Angela Risch,Myrto Barrdahl,Torkjel M. Sandanger,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Mattias Johansson,Paolo Vineis,Silvia Polidoro,Caroline L Relton,Gianluca Severi +33 more
TL;DR: Significant evidence is provided that smoking and possibly other factors lead to DNA methylation changes measurable in peripheral blood that may improve prediction of lung cancer risk, including smoking status and number of pack‐years.
Journal ArticleDOI
Association of DNA Methylation-Based Biological Age With Health Risk Factors and Overall and Cause-Specific Mortality.
Pierre Antoine Dugué,Pierre Antoine Dugué,Julie K. Bassett,Jihoon E. Joo,Laura Baglietto,Laura Baglietto,Laura Baglietto,Chol-Hee Jung,Ee Ming Wong,Giovanni Fiorito,Daniel F. Schmidt,Enes Makalic,Shuai Li,Margarita Moreno-Betancur,Margarita Moreno-Betancur,Daniel D. Buchanan,Daniel D. Buchanan,Paolo Vineis,Dallas R. English,Dallas R. English,John L. Hopper,Gianluca Severi,Melissa C. Southey,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Roger L. Milne,Roger L. Milne +27 more
TL;DR: DNA-methylation-based AA measures are associated with several major health risk factors, but these do not fully explain the association between AA and mortality, and future research should investigate what genetic and environmental factors determine AA.