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Efterpi Kostareli
Researcher at Queen's University Belfast
Publications - 21
Citations - 928
Efterpi Kostareli is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Chronic lymphocytic leukemia & IGHV@. The author has an hindex of 11, co-authored 19 publications receiving 811 citations. Previous affiliations of Efterpi Kostareli include University Hospital Heidelberg & German Cancer Research Center.
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Journal ArticleDOI
Cytogenetic evaluation and DNA interaction studies of the food colorants amaranth, erythrosine and tartrazine
Panagiotis Mpountoukas,Anastasia A. Pantazaki,Efterpi Kostareli,Pantelitsa Christodoulou,Dimitra Kareli,Stamatia Poliliou,Costas Mourelatos,Vasso Lambropoulou,Theodore Lialiaris +8 more
TL;DR: The results indicate that these food colorants had a toxic potential to human lymphocytes in vitro and it seems that they bind directly to DNA.
Journal ArticleDOI
HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas
Efterpi Kostareli,Dana Holzinger,Dana Holzinger,Olga Bogatyrova,Thomas Hielscher,Gunnar Wichmann,Michaela K. Keck,Bernd Lahrmann,Niels Grabe,Christa Flechtenmacher,Christopher R. Schmidt,Tanguy Y. Seiwert,Gerhard Dyckhoff,Andreas Dietz,Daniela Höfler,Michael Pawlita,Axel Benner,Franz X. Bosch,Peter K. Plinkert,Christoph Plass,Dieter Weichenhan,Jochen Hess,Jochen Hess +22 more
TL;DR: This study highlights specific alterations in global gene promoter methylation in HPV-driven OPSCCs and identifies a signature that predicts the clinical outcome inOPSCCs.
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Efficient Treg depletion induces T-cell infiltration and rejection of large tumors.
TL;DR: It is shown that 90–95% Treg depletion resulted in complete regression of large established tumors, whereas 70% depletion was ineffective, and it would be desirable to have reagents that allow high‐level depletion of Treg, which, in conjunction with treatment modalities such as vaccination, may concomitantly increase T‐cell activation and infiltration.
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Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
Efterpi Kostareli,A. Hadzidimitriou,Niki Stavroyianni,Nikos Darzentas,Anastasia Athanasiadou,Maria Gounari,V Bikos,Andreas Agathagelidis,Tasoula Touloumenidou,I Zorbas,Anastasia Kouvatsi,Nikolaos Laoutaris,Athanasios Fassas,Achilles Anagnostopoulos,C. Belessi,Kostas Stamatopoulos +15 more
TL;DR: Findings indicate that the interactions of CLL progenitor cells expressing distinctive IGHV4-34 BCRs with viral antigens/superantigens might facilitate clonal expansion and, eventually, leukemic transformation.
Journal ArticleDOI
Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
Lesley-Ann Sutton,Efterpi Kostareli,Anastasia Hadzidimitriou,Nikos Darzentas,Athanasios Tsaftaris,Achilles Anagnostopoulos,Richard Rosenquist,Kostas Stamatopoulos +7 more
TL;DR: A large-scale subcloning study of rearranged immunoglobulin heavy variable (IGHV) genes of diverse mutational status from 71 CLL cases finds that intense ID in the IGHV genes of selected cases, especially a subgroup of 13 IgG-switched cases expressing stereotyped, mutated I GHV4-34 rearrangements (subset 4), represents a unique phenomenon strongly correlated with the distinctive BCR of subset 4.