Maarit Hölttä-Vuori

TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.

TL;DR: It is suggested that seipin helps to connect newly formed LDs to the ER and that by stabilizing ER–LD contacts seipIn facilitates the incorporation of protein and lipid cargo into growing LDs in human cells.

TL;DR: This study employs atomistic simulations and experiments to characterize a cholesterol compound with fluorescent boron dipyrromethene difluoride linked to sterol carbon‐24 (BODIPY‐cholesterol), and concludes that this new probe closely mimics the membrane partitioning and trafficking of cholesterol and enables the direct monitoring of sterol movement by time‐lapse imaging using trace amounts of the probe.

TL;DR: Basic information on the lipid composition and distribution in zebrafish tissues, including lipoprotein metabolism, intestinal lipid absorption, the yolk lipids and their mobilization, as well as lipids in the nervous system are summarized.

TL;DR: The results suggest that in Rab11-overexpressing cells, deposition of cholesterol in recycling endosomes results in its impaired esterification, presumably due to defective recycling of cholesterol to the plasma membrane.