Elizabeth A. Molitor

TL;DR: It is found that elevated lipid quantities in hepatic macrophages caused by a high-fat diet persist long after reverting to a normal diet, hindering preclinical drug development and research into the mechanisms linking endolysosomal lipid accumulation to disease progression.

TL;DR: In this paper, liver-specific Tm6sf2 deletion impairs very low density lipoprotein (VLDL) secretion and either unchanged or increased hepatic steatosis, with no increased fibrosis.

TL;DR: It is shown that TCF reduced lipid storage, extended lifespan, and preserved neurological function in Npc1 mice, and substitution of an inactive analog for vorinostat in TCF revealed similar efficacy.

TL;DR: It is shown that hepatic A1CF overexpression selectively alters polysomal distribution and mRNA expression, promoting lipogenic, proliferative, and inflammatory pathways leading to HCC.

TL;DR: In this article, inducible inhibition of chylomicron assembly, as observed in intestine-specific microsomal triglyceride transfer protein knockout mice (Mttp-IKO), could retard NAFLD progression and/or reverse established fibrosis in two dietary models.