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Elizabeth Nacheva
Researcher at University College London
Publications - 7
Citations - 219
Elizabeth Nacheva is an academic researcher from University College London. The author has contributed to research in topics: Nuclear DNA & SNP array. The author has an hindex of 6, co-authored 7 publications receiving 177 citations.
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Journal ArticleDOI
Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains.
Katya Mokretar,Katya Mokretar,Daniel Pease,Jan-Willem Taanman,Aynur Soenmez,Ayesha Ejaz,Tammaryn Lashley,Helen Ling,Steve M. Gentleman,Henry Houlden,Janice L. Holton,Anthony H.V. Schapira,Elizabeth Nacheva,Christos Proukakis +13 more
TL;DR: Evidence of somatic SNCA gains in brain, more commonly in nigral dopaminergic neurons of Parkinson's disease than controls, negatively correlated with onset age, and possibly commonest in some multiple system atrophy cases is presented.
Journal ArticleDOI
A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism Phenotype-Genotype Correlations
Eleanna Kara,Aoife Kiely,Christos Proukakis,Nicola J. Giffin,Seth Love,Jason Hehir,Khadija Rantell,Amelie Pandraud,Dena G. Hernandez,Elizabeth Nacheva,Alan M. Pittman,Mike A. Nalls,Andrew B. Singleton,Tamas Revesz,Kailash P. Bhatia,Niall Quinn,John Hardy,Janice L. Holton,Henry Houlden +18 more
TL;DR: In this article, the authors reported the clinical and neuropathologic features of a family carrying a heterozygous 6.4 Mb duplication of the SNCA locus with an atypical clinical presentation strongly reminiscent of frontotemporal dementia and late-onset pallidopyramidal syndromes.
Journal ArticleDOI
DNA isolation protocol effects on nuclear DNA analysis by microarrays, droplet digital PCR, and whole genome sequencing, and on mitochondrial DNA copy number estimation.
Elizabeth Nacheva,Katya Mokretar,Aynur Soenmez,Alan Pittman,Colin Grace,Roberto Valli,Ayesha Ejaz,Selina Vattathil,Emanuela Maserati,Henry Houlden,Jan-Willem Taanman,Anthony H.V. Schapira,Christos Proukakis +12 more
TL;DR: Evidence is provided for significant method-dependent bias in DNA isolation from human brain, as reported in rat tissues, and which may contribute to array “waves”, and could affect copy number determination, and sequencing coverage.
Journal ArticleDOI
Another look at follicular lymphoma: immunophenotypic and molecular analyses identify distinct follicular lymphoma subgroups
Teresa Marafioti,Christiane Copie-Bergman,Christiane Copie-Bergman,Maria Calaminici,Jennifer C. Paterson,Vishvesh H. Shende,Hongxiang Liu,Maryse Baia,Alan D. Ramsay,Claudio Agostinelli,Josette Brière,Andrew Clear,Ming-Qing Du,Pier Paolo Piccaluga,Noraidah Masir,Elizabeth Nacheva,Pierre Sujobert,Kandavel Shanmugam,Thomas M. Grogan,Thomas M. Grogan,Simon P. Brooks,Asim Khwaja,Kirit M. Ardeshna,William Townsend,Stefano Pileri,Corinne Haioun,David C. Linch,John G. Gribben,Philippe Gaulard,Philippe Gaulard,Peter G. Isaacson +30 more
TL;DR: An immunohistochemical evaluation of stathmin, which is strongly expressed by germinal centre B cells, is included as a putative new marker for follicular lymphomas, particularly those with an atypical phenotype.
Journal ArticleDOI
Alteration of SMRT Tumor Suppressor Function in Transformed Non-Hodgkin Lymphomas
Lynda Li Song,Andrei Zlobin,Pushpankur Ghoshal,Qing Zhang,Christiane Houde,Sanne Weijzen,Qun Jiang,Elizabeth Nacheva,Danny Yagan,Eric Davis,Sylvie Galiègue-Zouitina,Daniel Catovsky,Thomas M. Grogan,Richard I. Fisher,Lucio Miele,Lionel J. Coignet,Lionel J. Coignet +16 more
TL;DR: It is shown that down-regulation of SMRT in the immortalized "Weinberg's model" cell lines induces transformation of the cells, and assessment of cDNA array profiles should further help to design a working model for SMRT involvement in non-Hodgkin lymphoma transformation as a novel, nonclassical tumor suppressor.