Showing papers by "Emmanuel L. Gautier published in 2023"
TL;DR: In this paper , the authors focus on understanding the metabolic variability of mononuclear phagocyte (MNP) subpopulations across tissues through metabolic network analysis applied to three large-scale transcriptional datasets: an ImmGen MNP open-source dataset of 337 samples across 26 tissues, a myeloid subset of ImmGen Phase I dataset (202 MNP samples), and a myELoid mouse single-cell RNA sequencing (scRNA-seq) dataset (51,364 cells) assembled based on Tabula Muris Senis.
2 citations
TL;DR: In this paper , the authors observed that short-term HFD induced dysbiosis, glucose intolerance and decreased intestinal RORγt+ CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells.
Abstract: Diet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (HFD) in which lipids are enriched at the expense of dietary fibers. Such nutritional challenge alters glucose homeostasis as well as intestinal immunity. Here, we observed that short-term HFD induced dysbiosis, glucose intolerance and decreased intestinal RORγt+ CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells. However, dietary fiber supplementation of HFD-fed animals was sufficient to maintain RORγt+ CD4 T cell subsets and microbial species known to induce them, alongside having a beneficial impact on glucose tolerance. Dietary fiber-mediated normalization of Th17 cells and amelioration of glucose handling required the cDC2 dendritic cell subset in HFD-fed animals, while IL-17 neutralization limited fibers impact on glucose tolerance. Overall, we uncover a novel and pivotal role of cDC2 in the control of the immune and metabolic effects of dietary fibers in the context of HFD feeding.
1 citations
TL;DR: In this article , cholesterol removal therapy with cyclodextrin reduced tumor burden in progressing tumor by suppressing the proliferation and expansion of epithelial progenitor cells of tumor origin in human lung adenocarcinoma.
1 citations
TL;DR: In this article , the authors discuss the key role of immune cells in the onset and progression of NASH, and discutons du rôle des cellules immunitaires dans le développement et la progression of la NASH.
1 citations
TL;DR: In this paper , the authors reported that the reduction in DiI transfer to HDL observed in AMI patients was unrelated to their acute phase state, and recruited another group of low HDL-C subjects with Tangier disease (n = 7).