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Enza Vernucci
Researcher at Eppley Institute for Research in Cancer and Allied Diseases
Publications - 24
Citations - 1286
Enza Vernucci is an academic researcher from Eppley Institute for Research in Cancer and Allied Diseases. The author has contributed to research in topics: Pancreatic cancer & Cancer cell. The author has an hindex of 14, co-authored 23 publications receiving 831 citations. Previous affiliations of Enza Vernucci include Sapienza University of Rome & Open University.
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Journal ArticleDOI
Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia.
Surendra K. Shukla,Spas Dimitrov Markov,Kuldeep S. Attri,Enza Vernucci,Ryan J. King,Aneesha Dasgupta,Paul M. Grandgenett,Michael A. Hollingsworth,Pankaj K. Singh,Fang Yu,Kamiya Mehla +10 more
TL;DR: The critical association between macrophages and cachexia phenotype in pancreatic cancer is identified and macrophage depletion attenuated systemic inflammation and muscle wasting in pancreatIC tumor-bearing mice.
Journal ArticleDOI
SIRT1–NOX4 signaling axis regulates cancer cachexia
Aneesha Dasgupta,Surendra K. Shukla,Enza Vernucci,Ryan J. King,Jaime Abrego,Scott E. Mulder,Nicholas J Mullen,Gavin Graves,Kyla Buettner,Ravi Thakur,Divya Murthy,Kuldeep S. Attri,Dezhen Wang,Nina V. Chaika,Camila G. Pacheco,Ibha Rai,Dannielle D. Engle,Paul M. Grandgenett,Michael Punsoni,Bradley N. Reames,Melissa Teoh-Fitzgerald,Rebecca E. Oberley-Deegan,Fang Yu,Kelsey Klute,Michael A. Hollingsworth,Matthew C. Zimmerman,Kamiya Mehla,Junichi Sadoshima,David A. Tuveson,Pankaj K. Singh,Pankaj K. Singh +30 more
TL;DR: It is established that the Sirt1–Nox4 signaling axis plays an essential role in the manifestation of pancreatic cancer cachexia, and inhibition of this axis abrogates the cachexia syndrome.
Journal ArticleDOI
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Tuo Hu,Tuo Hu,Surendra K. Shukla,Enza Vernucci,Chunbo He,Dezhen Wang,Ryan J. King,Kanupriya Jha,Kasturi Siddhanta,Kasturi Siddhanta,Nicholas J Mullen,Kuldeep S. Attri,Divya Murthy,Nina V. Chaika,Ravi Thakur,Scott E. Mulder,Scott E. Mulder,Camila G. Pacheco,Xiao Fu,Robin High,Fang Yu,Audrey J. Lazenby,Clemens Steegborn,Ping Lan,Kamiya Mehla,Dante Rotili,Sarika Chaudhary,Sergio Valente,Marco Tafani,Antonello Mai,Johan Auwerx,Eric Verdin,David A. Tuveson,Pankaj Singh +33 more
TL;DR: In this paper, the role of SIRT5 in the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) remains unknown, however, the role plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor or an oncogene, in different tumors.
Journal ArticleDOI
SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide
Ilaria Carnevale,Laura Pellegrini,Patrizia D'Aquila,Serena Saladini,Emanuela Lococo,Lucia Polletta,Enza Vernucci,Eleonora Foglio,Stefano Coppola,Luigi Sansone,Giuseppe Passarino,Dina Bellizzi,Matteo Antonio Russo,Massimo Fini,Marco Tafani +14 more
TL;DR: It is demonstrated that cells with low SIRT1 levels can maintain their resistance and survival by increasing SIRT3 expression, and it is speculated that acetylated ZF5 cannot bind and sequester SP1 that is free, then, to increase Sirt3 transcription.
Journal ArticleDOI
Sirtuins and resveratrol-derived compounds: a model for understanding the beneficial effects of the Mediterranean diet.
Matteo Antonio Russo,Luigi Sansone,Lucia Polletta,Alessandra Runci,Mohammad Mamunur Rashid,Elena De Santis,Enza Vernucci,Ilaria Carnevale,Marco Tafani +8 more
TL;DR: The state of the art leading to demonstrate the important role of sirtuins as principal intracellular mediators of the beneficial effects of the MD is described and how Mediterranean diet may influence microbioma composition and stem cells function is introduced.