N
Nina V. Chaika
Researcher at Eppley Institute for Research in Cancer and Allied Diseases
Publications - 37
Citations - 2618
Nina V. Chaika is an academic researcher from Eppley Institute for Research in Cancer and Allied Diseases. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 20, co-authored 33 publications receiving 1994 citations. Previous affiliations of Nina V. Chaika include University of Nebraska Medical Center.
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Journal ArticleDOI
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
Kirsten L. Bryant,Clint A. Stalnecker,Daniel Zeitouni,Jennifer E. Klomp,Sen Peng,Andrey P. Tikunov,Venugopal Gunda,Mariaelena Pierobon,Adele Waters,Samuel D. George,Garima Tomar,Björn Papke,G. Aaron Hobbs,Liang Yan,Tikvah K. Hayes,J. Nathaniel Diehl,Gennifer D. Goode,Nina V. Chaika,Yingxue Wang,Guo-Fang Zhang,Agnieszka K. Witkiewicz,Erik S. Knudsen,Emanuel F. Petricoin,Pankaj K. Singh,Jeffrey M. Macdonald,Nhan L. Tran,Costas A. Lyssiotis,Haoqiang Ying,Alec C. Kimmelman,Adrienne D. Cox,Channing J. Der +30 more
TL;DR: It is concluded that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC.
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MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Surendra K. Shukla,Vinee Purohit,Kamiya Mehla,Venugopal Gunda,Nina V. Chaika,Enza Vernucci,Ryan J. King,Jaime Abrego,Gennifer D. Goode,Aneesha Dasgupta,Alysha L. Illies,Teklab Gebregiworgis,Bingbing Dai,Jithesh J. Augustine,Divya Murthy,Kuldeep S. Attri,Oksana Mashadova,Paul M. Grandgenett,Robert Powers,Quan P. Ly,Audrey J. Lazenby,Jean L. Grem,Fang Yu,José M. Matés,John M. Asara,Jung Whan Kim,Jordan Hankins,Colin D. Weekes,Michael A. Hollingsworth,Natalie J. Serkova,Aaron R. Sasson,Jason B. Fleming,Jennifer M. Oliveto,Costas A. Lyssiotis,Lewis C. Cantley,Lyudmyla Berim,Pankaj K. Singh,Pankaj K. Singh +37 more
TL;DR: A widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer is established, whereby increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycytidine triphosphate (dCTP).
Journal ArticleDOI
Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–β Signaling
TL;DR: Data is presented showing that collagen I induces EMT in non-small cell lung cancer cell lines, which is prevented by blocking transforming growth factor (TGF)-beta3 signaling, and this data is consistent with the hypothesis that collagenI induces E MT in lung cancer cells by activating autocrine TGF- beta3 signaling.
Journal ArticleDOI
Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
Yasushi Shintani,Yuri Fukumoto,Nina V. Chaika,Robert A. Svoboda,Margaret J. Wheelock,Keith R. Johnson +5 more
TL;DR: The current study was designed to understand the pathway from collagen to N-cadherin up-regulation, which involves knocking down c-Jun NH2-terminal kinase and limited tumor growth and invasion in a mouse model for pancreatic cancer.
Journal ArticleDOI
Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia
Surendra K. Shukla,Teklab Gebregiworgis,Vinee Purohit,Vinee Purohit,Nina V. Chaika,Venugopal Gunda,Prakash Radhakrishnan,Kamiya Mehla,Iraklis I. Pipinos,Robert Powers,Fang Yu,Pankaj K. Singh +11 more
TL;DR: The studies demonstrate that the cachectic phenotype is in part due to metabolic alterations in tumor cells, which can be reverted by a ketogenic diet, causing reduced tumor growth and inhibition of muscle and body weight loss.