D
Dannielle D. Engle
Researcher at Cold Spring Harbor Laboratory
Publications - 34
Citations - 7128
Dannielle D. Engle is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 18, co-authored 28 publications receiving 4712 citations. Previous affiliations of Dannielle D. Engle include Lustgarten Foundation & Salk Institute for Biological Studies.
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Journal ArticleDOI
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Sylvia F. Boj,Chang-Il Hwang,Chang-Il Hwang,Lindsey A. Baker,Lindsey A. Baker,Iok In Christine Chio,Iok In Christine Chio,Dannielle D. Engle,Dannielle D. Engle,Vincenzo Corbo,Vincenzo Corbo,Myrthe Jager,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Hervé Tiriac,Hervé Tiriac,Mona S. Spector,Mona S. Spector,Ana Gracanin,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Kenneth H. Yu,Ruben van Boxtel,Meritxell Huch,Keith Rivera,John P. Wilson,Michael E. Feigin,Michael E. Feigin,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Christine M. Ardito-Abraham,Christine M. Ardito-Abraham,Michael Ludwig,Michael Ludwig,Ela Elyada,Ela Elyada,Brinda Alagesan,Brinda Alagesan,Brinda Alagesan,Giulia Biffi,Giulia Biffi,Georgi N. Yordanov,Georgi N. Yordanov,Bethany Delcuze,Bethany Delcuze,Brianna Creighton,Brianna Creighton,Kevin Wright,Kevin Wright,Young-Kyu Park,Young-Kyu Park,Folkert H.M. Morsink,I. Quintus Molenaar,Inne H.M. Borel Rinkes,Edwin Cuppen,Yuan Hao,Ying Jin,Isaac J. Nijman,Christine A. Iacobuzio-Donahue,Steven D. Leach,Darryl J. Pappin,Molly Hammell,David S. Klimstra,Olca Basturk,Ralph H. Hruban,G. J. A. Offerhaus,Robert G.J. Vries,Hans Clevers,David A. Tuveson,David A. Tuveson,David A. Tuveson +73 more
TL;DR: Comprehensive transcriptional and proteomic analyses of murine pancreatic organoids revealed genes and pathways altered during disease progression that demonstrate that organoids are a facile model system to discover characteristics of this deadly malignancy.
Journal ArticleDOI
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Daniel Öhlund,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Giulia Biffi,Giulia Biffi,Ela Elyada,Ela Elyada,Ana S. Almeida,Ana S. Almeida,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Vincenzo Corbo,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Stephen Hearn,Eun Jung Lee,Eun Jung Lee,Iok In Christine Chio,Iok In Christine Chio,Chang-Il Hwang,Chang-Il Hwang,Hervé Tiriac,Hervé Tiriac,Lindsey A. Baker,Lindsey A. Baker,Dannielle D. Engle,Dannielle D. Engle,Christine Feig,Anne Kultti,Mikala Egeblad,Douglas T. Fearon,James M. Crawford,Hans Clevers,Young-Kyu Park,Young-Kyu Park,David A. Tuveson,David A. Tuveson +40 more
TL;DR: Direct evidence for CAF heterogeneity in PDA tumor biology is provided, providing direct evidence for disease etiology and therapeutic development in mouse and human PDA tissue.
Journal ArticleDOI
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
Ela Elyada,Ela Elyada,Mohan Bolisetty,Pasquale Laise,William F. Flynn,Elise T. Courtois,Richard A. Burkhart,Jonathan Teinor,Pascal Belleau,Giulia Biffi,Giulia Biffi,Matthew S. Lucito,Matthew S. Lucito,Santhosh Sivajothi,Todd D. Armstrong,Dannielle D. Engle,Dannielle D. Engle,Dannielle D. Engle,Kenneth H. Yu,Yuan Hao,Christopher L. Wolfgang,Young-Kyu Park,Young-Kyu Park,Jonathan B. Preall,Elizabeth M. Jaffee,Andrea Califano,Paul Robson,David A. Tuveson,David A. Tuveson +28 more
TL;DR: A new population of CAFs that express MHC class II and CD74, but do not express classical co-stimulatory molecules are described, and it is found that they activate CD4+ T cells in an antigen-specific fashion in a model system, confirming their putative immune-modulatory capacity.
Journal ArticleDOI
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
Mara H. Sherman,Ruth T. Yu,Dannielle D. Engle,Ning Ding,Annette R. Atkins,Hervé Tiriac,Eric A. Collisson,Frances Connor,Terry Van Dyke,Serguei Kozlov,Philip Martin,Tiffany W. Tseng,David W. Dawson,Timothy R. Donahue,Atsushi Masamune,Tooru Shimosegawa,Minoti V. Apte,Jeremy S. Wilson,Beverly Ng,Beverly Ng,Sue Lynn Lau,Sue Lynn Lau,Sue Lynn Lau,Jenny E. Gunton,Geoffrey M. Wahl,Tony Hunter,Jeffrey A. Drebin,Peter J. O'Dwyer,Christopher Liddle,David A. Tuveson,Michael Downes,Ronald M. Evans,Ronald M. Evans +32 more
TL;DR: It is shown that VDR acts as a master transcriptional regulator of PSCs to reprise the quiescent state, resulting in induced stromal remodeling, increased intratumoral gemcitabine, reduced tumor volume, and a 57% increase in survival compared to chemotherapy alone.
Journal ArticleDOI
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Hervé Tiriac,Pascal Belleau,Dannielle D. Engle,Dennis Plenker,Astrid Deschênes,Tim D.D. Somerville,Fieke E. M. Froeling,Richard A. Burkhart,Robert E. Denroche,Gun-Ho Jang,Koji Miyabayashi,C. Megan Young,C. Megan Young,Hardik Patel,Michelle Ma,Joseph F. LaComb,Randze Lerie Palmaira,Ammar A. Javed,Jasmine Huynh,Molly E. Johnson,Kanika Arora,Nicolas Robine,Minita Shah,Rashesh Sanghvi,Austin Goetz,Cinthya Y. Lowder,Laura A. Martello,Else Driehuis,Nicolas Lecomte,Gokce Askan,Christine A. Iacobuzio-Donahue,Hans Clevers,Laura D. Wood,Ralph H. Hruban,Elizabeth D. Thompson,Andrew J. Aguirre,Brian M. Wolpin,Aaron R. Sasson,Joseph Kim,Maoxin Wu,Juan Carlos Bucobo,Peter J. Allen,Divyesh V. Sejpal,William Nealon,James Sullivan,Jordan M. Winter,Phyllis A. Gimotty,Jean L. Grem,Dominick J. DiMaio,Jonathan M. Buscaglia,Paul M. Grandgenett,Jonathan R. Brody,Michael A. Hollingsworth,Grainne M. O'Kane,Faiyaz Notta,Edward J. Kim,James M. Crawford,Craig Devoe,Allyson J. Ocean,Christopher L. Wolfgang,Kenneth H. Yu,Ellen Li,Christopher R. Vakoc,Benjamin Hubert,Sandra Fischer,Sandra Fischer,Julie M. Wilson,Richard A. Moffitt,Jennifer J. Knox,Alexander Krasnitz,Steven Gallinger,Steven Gallinger,Steven Gallinger,David A. Tuveson +73 more
TL;DR: A pancreatic cancer patient-derived organoid (PDO) library is generated that recapitulates the mutational spectrum and transcriptional subtypes of primary Pancreatic cancer and proposes that combined molecular and therapeutic profiling of PDOs may predict clinical response and enable prospective therapeutic selection.