E
Eric Johannsen
Researcher at University of Wisconsin-Madison
Publications - 70
Citations - 4911
Eric Johannsen is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Epstein–Barr virus & Lytic cycle. The author has an hindex of 34, co-authored 65 publications receiving 4403 citations. Previous affiliations of Eric Johannsen include Brigham and Women's Hospital & Harvard University.
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Journal ArticleDOI
Proteins of purified Epstein-Barr virus
Eric Johannsen,Micah A. Luftig,Michael R. Chase,Steve Weicksel,Ellen Cahir-McFarland,Diego Illanes,David A. Sarracino,Elliott Kieff +7 more
TL;DR: Mature Epstein-Barr virus was purified from the culture medium of infected lymphocytes made functionally conditional for Zta activation of lytic replication by an in-frame fusion with a mutant estrogen receptor.
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Epstein–Barr virus and virus human protein interaction maps
Michael A. Calderwood,Kavitha Venkatesan,Li Xing,Michael R. Chase,Alexei Vazquez,Amy M. Holthaus,Alexandra E. Ewence,Ning Li,Tomoko Hirozane-Kishikawa,David E. Hill,Marc Vidal,Elliott Kieff,Eric Johannsen +12 more
TL;DR: The authors' EBV–EBV interactome map is enriched for interactions among proteins in the same evolutionary class, and human proteins targeted by EBV proteins were enriched for highly connected or “hub” proteins and for proteins with relatively short paths to all other proteins inThe human interactome network.
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The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein.
TL;DR: Purified or recombinant in vitro-translated J kappa binds to the MNYYGTGGGAA EBNA-2 response element sequence and interacts with EBNA, but does not bind to theJ kappa 1 heptamer recombination signal sequence.
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Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Orit Rozenblatt-Rosen,Rahul C. Deo,Rahul C. Deo,Megha Padi,Guillaume Adelmant,Michael A. Calderwood,Thomas Rolland,Miranda Grace,Miranda Grace,Amélie Dricot,Manor Askenazi,Maria Tavares,Sam Pevzner,Sam Pevzner,Fieda Abderazzaq,Danielle Byrdsong,Anne-Ruxandra Carvunis,Alyce A. Chen,Alyce A. Chen,Jingwei Cheng,Jingwei Cheng,Mick Correll,Melissa Duarte,Melissa Duarte,Changyu Fan,Mariet C.W. Feltkamp,Scott B. Ficarro,Rachel Franchi,Rachel Franchi,Brijesh K. Garg,Natali Gulbahce,Tong Hao,Amy M. Holthaus,Amy M. Holthaus,Robert James,Anna Korkhin,Anna Korkhin,Larisa Litovchick,Larisa Litovchick,Jessica C. Mar,Theodore R. Pak,Sabrina Rabello,Renee Rubio,Yun Shen,Saurav Singh,Jennifer M. Spangle,Jennifer M. Spangle,Murat Tasan,Murat Tasan,Shelly Wanamaker,Shelly Wanamaker,James T. Webber,Jennifer Roecklein-Canfield,Jennifer Roecklein-Canfield,Eric Johannsen,Eric Johannsen,Albert-László Barabási,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Elliott Kieff,Elliott Kieff,Michael E. Cusick,David E. Hill,Karl Münger,Karl Münger,Jarrod A. Marto,John Quackenbush,Frederick P. Roth,James A. DeCaprio,James A. DeCaprio,Marc Vidal +71 more
TL;DR: It is shown that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations, to increase the specificity of cancer gene identification.
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Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.
TL;DR: EBNA-2 transactivation of the LMP-1 promoter is dependent on interaction with at least two distinct sequence-specific DNA-binding proteins, J kappa and PU.1.