Melissa Duarte

TL;DR: A proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins is described.

TL;DR: In this article, the preferential sensitivity of triple negative breast cancer (TNBC) cells to BET bromodomain inhibition in vitro and in vivo has been investigated and a rationale for clinical investigation and further motivation to understand mechanisms of resistance.

TL;DR: It is shown that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations, to increase the specificity of cancer gene identification.

TL;DR: The causal role of EZH2 overexpression in NSCLC is demonstrated with new genetically engineered mouse models of lung adenocarcinoma, and a potent open-source EZh2 inhibitor, JQEZ5, is developed that promotes regression of EzH2-driven tumors in vivo, revealing a potential role for anti-EZH1 therapy in lung cancer and providing the rationale for epigenetic therapy in a subset of lung cancer.

TL;DR: Fixed-tissue chromatin immunoprecipitation sequencing (FiT-seq) is described, a method that enables reliable extraction of soluble chromatin from formalin-fixed paraffin-embedded (FFPE) tissue samples for accurate detection of histone marks.