A
Anna Korkhin
Researcher at Harvard University
Publications - 3
Citations - 395
Anna Korkhin is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Heterologous expression. The author has an hindex of 2, co-authored 3 publications receiving 352 citations. Previous affiliations of Anna Korkhin include Brigham and Women's Hospital.
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Journal ArticleDOI
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Orit Rozenblatt-Rosen,Rahul C. Deo,Rahul C. Deo,Megha Padi,Guillaume Adelmant,Michael A. Calderwood,Thomas Rolland,Miranda Grace,Miranda Grace,Amélie Dricot,Manor Askenazi,Maria Tavares,Sam Pevzner,Sam Pevzner,Fieda Abderazzaq,Danielle Byrdsong,Anne-Ruxandra Carvunis,Alyce A. Chen,Alyce A. Chen,Jingwei Cheng,Jingwei Cheng,Mick Correll,Melissa Duarte,Melissa Duarte,Changyu Fan,Mariet C.W. Feltkamp,Scott B. Ficarro,Rachel Franchi,Rachel Franchi,Brijesh K. Garg,Natali Gulbahce,Tong Hao,Amy M. Holthaus,Amy M. Holthaus,Robert James,Anna Korkhin,Anna Korkhin,Larisa Litovchick,Larisa Litovchick,Jessica C. Mar,Theodore R. Pak,Sabrina Rabello,Renee Rubio,Yun Shen,Saurav Singh,Jennifer M. Spangle,Jennifer M. Spangle,Murat Tasan,Murat Tasan,Shelly Wanamaker,Shelly Wanamaker,James T. Webber,Jennifer Roecklein-Canfield,Jennifer Roecklein-Canfield,Eric Johannsen,Eric Johannsen,Albert-László Barabási,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Elliott Kieff,Elliott Kieff,Michael E. Cusick,David E. Hill,Karl Münger,Karl Münger,Jarrod A. Marto,John Quackenbush,Frederick P. Roth,James A. DeCaprio,James A. DeCaprio,Marc Vidal +71 more
TL;DR: It is shown that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations, to increase the specificity of cancer gene identification.
Journal ArticleDOI
Identification of FAM111A as an SV40 Host Range Restriction and Adenovirus Helper Factor
Debrah A. Fine,Orit Rozenblatt-Rosen,Megha Padi,Anna Korkhin,Robert L. James,Guillaume Adelmant,Rosa Yoon,Luxuan Guo,Luxuan Guo,Christian Berrios,Ying Zhang,Michael A. Calderwood,Soundarapandian Velmurgan,Jingwei Cheng,Jingwei Cheng,Jarrod A. Marto,David E. Hill,Michael E. Cusick,Marc Vidal,Laurence Florens,Michael P. Washburn,Michael P. Washburn,Larisa Litovchick,Larisa Litovchick,James A. DeCaprio +24 more
TL;DR: Depletion of FAM111A recapitulated the effects of heterologous expression of the LT C-terminal region, including increased viral gene expression and lytic infection of SV40 host range mutants and adenovirus replication in restrictive cells.
Supplementary Material 23
Orit Rozenblatt-Rosen,Rahul C. Deo,Megha Padi,Guillaume Adelmant,Michael A. Calderwood,Thomas Rolland,Miranda Grace,Amélie Dricot,Manor Askenazi,Maria Tavares,Sam Pevzner,Fieda Abderazzaq,Danielle Byrdsong,Anne-Ruxandra Carvunis,Alyce A. Chen,Jingwei Cheng,Mick Correll,Melissa Duarte,Changyu Fan,Mariet C.W. Feltkamp,Scott B. Ficarro,Rachel Franchi,Brijesh K. Garg,Natali Gulbahce,Tong Hao,Amy M. Holthaus,Robert James,Anna Korkhin,Larisa Litovchick,Jessica C. Mar,Theodore R. Pak,Sabrina Rabello,Renee Rubio,Yun Shen,Saurav Singh,Jennifer M. Spangle,Murat Tasan,Shelly Wanamaker,James T. Webber,Jennifer Roecklein-Canfield,Eric Johannsen,Albert-László Barabási,Rameen Beroukhim,Elliott Kieff,Michael E. Cusick,David E. Hill,Karl Münger,Jarrod A. Marto,John Quackenbush,Frederick P. Roth,James A. DeCaprio,Marc Vidal +51 more