Erik Serrao

TL;DR: The combined approach of morphogen-driven differentiation and transcription-factor-mediated cell fate conversion produces haem atopoietic stem and progenitor cells from pluripotent stem cells and holds promise for modelling haematopoetic disease in humanized mice and for therapeutic strategies in genetic blood disorders.

TL;DR: Next-generation sequencing of near-full-length single HIV-1 genomes and corresponding chromosomal integration sites suggest that a distinct configuration of the proviral reservoir represents a structural correlate of natural viral control, and that the quality, rather than the quantity, of viral reservoirs can be an important distinguishing feature for a functional cure of HIV- 1 infection.

TL;DR: It is concluded that integration targeting proceeds via two distinct mechanisms: capsid-CPSF6 binding directs HIV-1 to actively transcribed euchromatin, where the integrase-LEDGF/p75 interaction drives integration into gene bodies.

TL;DR: It is proposed that most of these me-too MK-0518 analogues may experience a low success rate against raltegravir-resistant HIV strains and the development of drugs with new mechanisms of inhibitory action and/or new active substituents may be a more successful route to take in theDevelopment of second- and third-generation IN inhibitors.

TL;DR: It is shown that the prototype foamy virus (PFV) intasome is proficient at stable capture of nucleosomes as targets for integration, and the molecular basis for nucleosome capture by the viral DNA recombination machinery and the underlying nucleosomal plasticity that allows integration is elucidated.