E
Erwin Neher
Researcher at Max Planck Society
Publications - 208
Citations - 54453
Erwin Neher is an academic researcher from Max Planck Society. The author has contributed to research in topics: Exocytosis & Calyx of Held. The author has an hindex of 107, co-authored 200 publications receiving 53036 citations. Previous affiliations of Erwin Neher include University of Giessen & Macau University of Science and Technology.
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Journal ArticleDOI
Highly Nonlinear Photodamage in Two-Photon Fluorescence Microscopy
Alexander Hopt,Erwin Neher +1 more
TL;DR: This study studied this kind of damage in bovine adrenal chromaffin cells, using two different indicators of damage: changes in resting [Ca(2+)] level and the degranulation reaction, and found that damage is proportional to the integral (over space and time) of light intensity raised to a power approximately 2.5.
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Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes.
TL;DR: Simultaneous fluorescence and whole‐cell current measurements using the calcium indicator dye fura‐2 were made in HEK 293 cells expressing recombinant glutamate receptor (GluR) channels, and fractional Ca2+ currents were determined, demonstrating that editing of the Q/R site of GluR‐B subunits decreases Ca2- inflow through heteromeric AMPARs.
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Two Fast Transient Current Components during Voltage Clamp on Snail Neurons
TL;DR: Voltage clamp currents from medium sized ganglion cells of Helix pomatia have a fast transient outward current component in addition to the usually observed inward and outward currents.
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Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release
Andrea Betz,Uri Ashery,Michael Rickmann,Iris Augustin,Erwin Neher,Thomas C. Südhof,Jens Rettig,Nils Brose +7 more
TL;DR: It is demonstrated that Munc13-1 is a presynaptic high-affinity phorbol ester and diacylglycerol receptor with ligand affinities similar to those of protein kinase C to regulate neurotransmitter secretion.
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Single Na + channel currents observed in cultured rat muscle cells
Fred J. Sigworth,Erwin Neher +1 more
TL;DR: The first observations of currents through individual Na+ channels under physiological conditions using an improved version of the extracellular patch-clamp technique on cultured rat muscle cells support earlier inferences about channel gating and show a single-channel conductance of approximately 18 pS.