E
Erwin Neher
Researcher at Max Planck Society
Publications - 208
Citations - 54453
Erwin Neher is an academic researcher from Max Planck Society. The author has contributed to research in topics: Exocytosis & Calyx of Held. The author has an hindex of 107, co-authored 200 publications receiving 53036 citations. Previous affiliations of Erwin Neher include University of Giessen & Macau University of Science and Technology.
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A two-step model of secretion control in neuroendocrine cells.
TL;DR: A two-step model of secretion that allows one to simulate the dynamics of a pool of release-ready granules for different time courses of free intracellular Ca concentration [Ca2+]i and predicts the occurrence of secretory depression and augmentation under appropriate conditions.
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Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I
Thomas Voets,Tobias Moser,Per-Eric Lund,Robert H. Chow,Martin Geppert,Thomas C. Südhof,Erwin Neher +6 more
TL;DR: These findings demonstrate that synaptotagmin I is required for rapid, highly Ca2+-sensitive LDCV exocytosis and indicate that it regulates the equilibrium between a slowly releasable and a readily releasables state of the fusion machinery.
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Ultrastructural Organization of Bovine Chromaffin Cell Cortex—Analysis by Cryofixation and Morphometry of Aspects Pertinent to Exocytosis
TL;DR: Analysis of ultrathin sections from isolated bovine chromaffin cells grown on plastic support, after fast freezing, by quantitative electron microscopy determined the size and intracellular distribution of dense core vesicles (DVs or Chromaffin granules) and of clear vesicle (CVs) and found that DVs appear randomly packed inside cells.
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Time course of Ca2+ concentration triggering exocytosis in neuroendocrine cells
TL;DR: The findings of the slower time course and the lower peak [Ca2+]i suggest that in chromaffin cells, unlike synapses, Ca2+ channels and vesicles are not strictly colocalized, consistent with previously published data on dense-core vesicle secretion from diverse cell types.
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Electrical Measurements on Endomembranes
Adam Bertl,Eduardo Blumwald,Roberto Coronado,Robert S. Eisenberg,Goeff Findlay,Dietrich Gradmann,Bertil Hille,Kurt Köhler,Hans Albert Kolb,Enid A. C. MacRobbie,Gerhard Meissner,Christopher Miller,Erwin Neher,Philip Palade,Omar Pantoja,Dale Sanders,Julian I. Schroeder,Clifford L. Slayman,Roger M. Spanswick,Alan R. Walker,Alan J. Williams +20 more