Etienne Caron

TL;DR: Tumour-specific mutant proteins are identified as a major class of T-cell rejection antigens following anti-PD-1 and/or anti-CTLA-4 therapy of mice bearing progressively growing sarcomas, and it is shown that therapeutic synthetic long-peptide vaccines incorporating these mutant epitopes induce tumour rejection comparably to checkpoint blockade immunotherapy.

TL;DR: In this paper, the authors present a compendium of highly specific assays covering more than 10,000 human proteins and enabling their targeted analysis in SWATH-MS datasets acquired from research or clinical specimens.

TL;DR: A comprehensive map of the mTOR signaling network, which includes 964 species connected by 777 reactions, is presented, which complies with both the systems biology markup language (SBML) and graphical notation (SBGN) for computational analysis and graphical representation, respectively.

TL;DR: A stress model of chronic pain is supported suggesting that the sustained endocrine stress response observed in individuals with a smaller hippocampii induces changes in the function of the hippocampal complex that may contribute to the persistent pain states.

TL;DR: In this article, the authors summarize established isolation techniques as well as emerging mass spectrometry-based platforms (i.e., SWATH-MS) to identify and quantify MHC-associated peptides.