E
Evangelia K. Papachristou
Researcher at University of Cambridge
Publications - 33
Citations - 1357
Evangelia K. Papachristou is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Biology. The author has an hindex of 14, co-authored 22 publications receiving 810 citations. Previous affiliations of Evangelia K. Papachristou include University of Southampton & University of Thessaly.
Papers
More filters
Journal ArticleDOI
Asparagine bioavailability governs metastasis in a model of breast cancer
Simon R.V. Knott,Simon R.V. Knott,Simon R.V. Knott,Elvin Wagenblast,Elvin Wagenblast,Elvin Wagenblast,Showkhin Khan,Sun Y. Kim,Mar Soto,Michel Wagner,Marc-Olivier Turgeon,Lisa Fish,Nicolas Erard,Annika L. Gable,Ashley R. Maceli,Steffen Dickopf,Evangelia K. Papachristou,Clive D'Santos,Lisa A. Carey,John E. Wilkinson,J. Chuck Harrell,Charles M. Perou,Hani Goodarzi,George Poulogiannis,George Poulogiannis,Gregory J. Hannon,Gregory J. Hannon +26 more
TL;DR: It is shown that asparagine bioavailability strongly influences metastatic potential, providing at least one potential mechanism for how the bioavailability of a single amino acid could regulate metastatic progression.
Journal ArticleDOI
Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes
Hisham Mohammed,Chris Taylor,Gordon D Brown,Evangelia K. Papachristou,Jason S. Carroll,Clive D'Santos +5 more
TL;DR: This work has shown that by using antibodies against the endogenous target, the cross-linked complex is immunoprecipitated, rigorously washed, and then digested into peptides while avoiding antibody contamination (on-bead digestion).
Journal ArticleDOI
IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
Rasmus Siersbæk,Valentina Scabia,Sankari Nagarajan,Igor Chernukhin,Evangelia K. Papachristou,Rebecca Broome,Simon J Johnston,Stacey E. P. Joosten,Andrew R. Green,Sanjeev Kumar,Julia P. G. Jones,Soleilmane Omarjee,Ruben Alvarez-Fernandez,Silvia Glont,Sarah J. Aitken,Sarah J. Aitken,Kamal Kishore,Danya Cheeseman,Emad A. Rakha,Clive D'Santos,Wilbert Zwart,Wilbert Zwart,Alasdair Russell,Cathrin Brisken,Jason S. Carroll +24 more
TL;DR: It is shown that inhibition of STAT3 activity using the JAK inhibitor ruxolitinib decreases breast cancer invasion in vivo, highlighting the potential of IL6/STAT3-targeted therapies in ER+ breast cancer.
Journal ArticleDOI
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
Shaokun Shu,Hua-Jun Wu,Jennifer Y Ge,Jennifer Y Ge,Rhamy Zeid,Isaac S. Harris,Bojana Jovanovic,Bojana Jovanovic,Katherine Murphy,Binbin Wang,Xintao Qiu,Jennifer E. Endress,Jaime M. Reyes,Klothilda Lim,Alba Font-Tello,Sudeepa Syamala,Tengfei Xiao,Chandra Sekhar Reddy Chilamakuri,Evangelia K. Papachristou,Clive D'Santos,Jayati Anand,Kunihiko Hinohara,Wei Li,Tom O. McDonald,Adrienne M. Luoma,Rebecca Modiste,Quang-Dé Nguyen,Brittany C. Michel,Paloma Cejas,Cigall Kadoch,Cigall Kadoch,Jacob D. Jaffe,Kai W. Wucherpfennig,Jun Qi,X. Shirley Liu,Henry W. Long,Myles Brown,Jason S. Carroll,Joan S. Brugge,James E. Bradner,Franziska Michor,Kornelia Polyak +41 more
TL;DR: Using CRISPR and small-molecule inhibitor screens combined with comprehensive molecular profiling of BBDI response and resistance, synthetic lethal interactions with BBDIs and genes that, when deleted, confer resistance are identified.
Journal ArticleDOI
A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.
Evangelia K. Papachristou,Kamal Kishore,Andrew N Holding,Kate Harvey,Theodoros I. Roumeliotis,Chandra Sekhar Reddy Chilamakuri,Soleilmane Omarjee,Kee Ming Chia,Alexander Swarbrick,Alexander Swarbrick,Elgene Lim,Elgene Lim,Florian Markowetz,Matthew D. Eldridge,Rasmus Siersbæk,Clive D'Santos,Jason S. Carroll +16 more
TL;DR: A sensitive mass spectrometry-based method to monitor the dynamic interactions of endogenous chromatin-associated protein complexes in clinical samples and identifies endogenous ERα-associated proteins in human Patient-Derived Xenograft tumours and in primary human breast cancer clinical tissue.