Evgenia Ntini

TL;DR: It is found that early co-transcriptional m 6A deposition near splice junctions promotes fast splicing, while m6A modifications in introns are associated with long, slowly processed introns and alternative splicing events.

TL;DR: A maternally expressed, imprinted lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure is identified and it is demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper.

TL;DR: The paper uses a recently developed algorithm to predict tissue-specific enhancers, PreSTIGE, that is based on the H3K4me1 mark and tissue specific expression of mRNAs, and identifies 2,695 long ncRNAs annotated by E NCODE (corresponding to 28% of all ENCODE annotated long n cRNAs) that overlap tissue- specific enhancers.

TL;DR: Evidence is provided that release of the long ncRNA AROD from chromatin enhances DKK1 transcription, and it is proposed that the post-transcriptional release of a subset oflong ncRNAs from the chromatin-associated template plays an important role in their function as transcription regulators.

TL;DR: Co-transcription of ncRNA-RB1 and RB1 provides a positive link between the expression of the two tumor suppressors RB1 and the immune-relevant CALR protein, exemplifies disease-relevant co-regulation of two distinct gene products.