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Isabella Gaziano
Researcher at Max Planck Society
Publications - 6
Citations - 147
Isabella Gaziano is an academic researcher from Max Planck Society. The author has contributed to research in topics: Receptor & Adipose tissue. The author has an hindex of 3, co-authored 3 publications receiving 77 citations. Previous affiliations of Isabella Gaziano include University of Cologne & University of Hamburg.
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Journal ArticleDOI
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Elena Schmidt,Elena Schmidt,Ines Dhaouadi,Ines Dhaouadi,Isabella Gaziano,Isabella Gaziano,Matteo Oliverio,Matteo Oliverio,Paul Klemm,Paul Klemm,Motoharu Awazawa,Motoharu Awazawa,Gerfried Mitterer,Eduardo Fernandez-Rebollo,Eduardo Fernandez-Rebollo,Marta Pradas-Juni,Marta Pradas-Juni,Marta Pradas-Juni,Wolfgang Wagner,Philipp Hammerschmidt,Philipp Hammerschmidt,Rute Loureiro,Rute Loureiro,Rute Loureiro,Christoph A. Kiefer,Nils R. Hansmeier,Nils R. Hansmeier,Sajjad Khani,Sajjad Khani,Matteo Bergami,Markus Heine,Evgenia Ntini,Peter Frommolt,Peter Zentis,Ulf Andersson Ørom,Jörg Heeren,Matthias Blüher,Martin Bilban,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld +40 more
TL;DR: A maternally expressed, imprinted lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure is identified and it is demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper.
Journal ArticleDOI
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
Nasim Biglari,Nasim Biglari,Isabella Gaziano,Isabella Gaziano,Jonas Schumacher,Jonas Schumacher,Jan Radermacher,Lars Paeger,Paul Klemm,Paul Klemm,Weiyi Chen,Weiyi Chen,Svenja Corneliussen,Claudia M. Wunderlich,Claudia M. Wunderlich,Michael Sué,Stefan Vollmar,Tim Klöckener,Tim Klöckener,Tamara Sotelo-Hitschfeld,Tamara Sotelo-Hitschfeld,Amin Abbasloo,Frank Edenhofer,Frank Reimann,Fiona M. Gribble,Henning Fenselau,Henning Fenselau,Peter Kloppenburg,Frank Thomas Wunderlich,Frank Thomas Wunderlich,Jens C. Brüning +30 more
TL;DR: In this article, intersectional Cre/Dre-dependent recombination allowed for successful labeling, translational profiling and functional characterization of distinct POMC neurons expressing the leptin receptor (Lepr) and glucagon like peptide 1 receptor (Glp1r).
Journal ArticleDOI
Differential effects of Calca-derived peptides in male mice with diet-induced obesity.
Alexander Bartelt,Anke Jeschke,Brigitte Müller,Isabella Gaziano,Michelle Morales,Timur A. Yorgan,Timo Heckt,Markus Heine,Robert F. Gagel,Ronald B. Emeson,Michael Amling,Andreas Niemeier,Jörg Heeren,Thorsten Schinke,Johannes Keller +14 more
TL;DR: This study provides the first comparative analyses of the roles of Calca-derived peptides and the CTR in metabolic disease, demonstrating that the CT/CTR axis is involved in regulating plasma cholesterol levels while Calca seems to have a detrimental effect in the context of metabolic disease.
Posted ContentDOI
Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function
Sajjad Khani,Hande Topel,Ajeetha Josephrajan,Bjørk Ditlev Larsen,Ana Rita Albuquerque de Almeida Tavanez,Michael J. Gaudry,Philipp Leyendecker,Natasa Stanic,Isabella Gaziano,Nils R. Hansmeier,Elena Schmidt,Paul Klemm,Lara-Marie Vagliano,Christoph Andreas Engelhard,Søren Nielsen,Naja Z. Jespersen,Rizwan Rehimi,Sabrina Gohlke,Peter Frommolt,Thorsten Gnad,Alvaro Rada-Iglesias,Marta Pradas-Juni,Tim J. Schulz,F. Thomas Wunderlich,Alexander Pfeifer,Martin Jastroch,Dagmar Wachten,Jan-Wilhelm Kornfeld +27 more
TL;DR: It is demonstrated that ADCY3, an adenylyl cyclase whose expression is induced during cold exposure and regulates cAMP homeostasis in thermogenic fat, is dispensable for BAT function in lean mice, but becomes critical during obesity.
Dopamine-inhibited POMC Drd2+ neurons in the ARC acutely regulate feeding and body temperature
Isabella Gaziano,Svenja Corneliussen,Nasim Biglari,René Neuhaus,Linyan Shen,Tamara Sotelo-Hitschfeld,Paul Klemm,Lukas Steuernagel,Alain J. De Solis,Weiyi Chen,F. Thomas Wunderlich,Peter Kloppenburg,Jens C. Brüning +12 more
TL;DR: In this paper , the authors demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake, promoting Agouti related peptide (AgRP)/neuropeptide Y (NPY) neurons and a large proportion of Drd2-expressing anorexigenic proopiomelanocortin (POMC) neurons.