E
Elena Schmidt
Researcher at Max Planck Society
Publications - 5
Citations - 217
Elena Schmidt is an academic researcher from Max Planck Society. The author has contributed to research in topics: Brown adipose tissue & Adipose tissue. The author has an hindex of 4, co-authored 4 publications receiving 152 citations. Previous affiliations of Elena Schmidt include University of Cologne.
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Journal ArticleDOI
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Elena Schmidt,Elena Schmidt,Ines Dhaouadi,Ines Dhaouadi,Isabella Gaziano,Isabella Gaziano,Matteo Oliverio,Matteo Oliverio,Paul Klemm,Paul Klemm,Motoharu Awazawa,Motoharu Awazawa,Gerfried Mitterer,Eduardo Fernandez-Rebollo,Eduardo Fernandez-Rebollo,Marta Pradas-Juni,Marta Pradas-Juni,Marta Pradas-Juni,Wolfgang Wagner,Philipp Hammerschmidt,Philipp Hammerschmidt,Rute Loureiro,Rute Loureiro,Rute Loureiro,Christoph A. Kiefer,Nils R. Hansmeier,Nils R. Hansmeier,Sajjad Khani,Sajjad Khani,Matteo Bergami,Markus Heine,Evgenia Ntini,Peter Frommolt,Peter Zentis,Ulf Andersson Ørom,Jörg Heeren,Matthias Blüher,Martin Bilban,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld +40 more
TL;DR: A maternally expressed, imprinted lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure is identified and it is demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper.
Journal ArticleDOI
Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function
Matteo Oliverio,Matteo Oliverio,Elena Schmidt,Elena Schmidt,Jan Mauer,Jan Mauer,Jan Mauer,Catherina Baitzel,Catherina Baitzel,Nils R. Hansmeier,Nils R. Hansmeier,Sajjad Khani,Sajjad Khani,Sandra Konieczka,Sandra Konieczka,Marta Pradas-Juni,Marta Pradas-Juni,Susanne Brodesser,Trieu-My Van,Deniz Bartsch,Deniz Bartsch,Hella S. Brönneke,Hella S. Brönneke,Markus Heine,Hans Hilpert,Emilio Tarcitano,George A. Garinis,Peter Frommolt,Jörg Heeren,Marcelo A. Mori,Jens C. Brüning,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld +32 more
TL;DR: Dicer1–miR-328–Bace1 signalling as a determinant of BAT function is revealed, and the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases but also ageing- and obesity-associated impairments ofBAT function is highlighted.
Journal ArticleDOI
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
Marta Pradas-Juni,Marta Pradas-Juni,Marta Pradas-Juni,Nils R. Hansmeier,Nils R. Hansmeier,Jenny C. Link,Elena Schmidt,Elena Schmidt,Bjørk Ditlev Larsen,Paul Klemm,Paul Klemm,Nicola Meola,Hande Topel,Hande Topel,Rute Loureiro,Rute Loureiro,Rute Loureiro,Ines Dhaouadi,Ines Dhaouadi,Christoph A. Kiefer,Robin Schwarzer,Sajjad Khani,Sajjad Khani,Matteo Oliverio,Matteo Oliverio,Motoharu Awazawa,Peter Frommolt,Joerg Heeren,Ludger Scheja,Markus Heine,Christoph Dieterich,Hildegard Büning,Ling Yang,Ling Yang,Haiming Cao,Dario F. De Jesus,Rohit N. Kulkarni,Branko Zevnik,Simon E. Tröder,Uwe Knippschild,Peter A. Edwards,Richard G. Lee,Masayuki Yamamoto,Igor Ulitsky,Eduardo Fernandez-Rebollo,Thomas Q. de Aguiar Vallim,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld +48 more
TL;DR: A transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice is described, and it is found that obesity-repressed LincIRS2 is controlled by MAFG and that genetic and RNAi-mediated Linc IRS2 loss causes elevated blood glucose, insulin resistance and aberrant glucose output in lean mice.
Journal ArticleDOI
Decoding Lamarck—transgenerational control of metabolism by noncoding RNAs
TL;DR: The current knowledge about ETI in lower and in higher organisms as well as in human cohorts is summarized and epigenetic principles potentially underlying this nongenetic mode of heredity are elaborated on.
Posted ContentDOI
Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function
Sajjad Khani,Hande Topel,Ajeetha Josephrajan,Bjørk Ditlev Larsen,Ana Rita Albuquerque de Almeida Tavanez,Michael J. Gaudry,Philipp Leyendecker,Natasa Stanic,Isabella Gaziano,Nils R. Hansmeier,Elena Schmidt,Paul Klemm,Lara-Marie Vagliano,Christoph Andreas Engelhard,Søren Nielsen,Naja Z. Jespersen,Rizwan Rehimi,Sabrina Gohlke,Peter Frommolt,Thorsten Gnad,Alvaro Rada-Iglesias,Marta Pradas-Juni,Tim J. Schulz,F. Thomas Wunderlich,Alexander Pfeifer,Martin Jastroch,Dagmar Wachten,Jan-Wilhelm Kornfeld +27 more
TL;DR: It is demonstrated that ADCY3, an adenylyl cyclase whose expression is induced during cold exposure and regulates cAMP homeostasis in thermogenic fat, is dispensable for BAT function in lean mice, but becomes critical during obesity.