J
Jörg Heeren
Researcher at University of Hamburg
Publications - 30
Citations - 1330
Jörg Heeren is an academic researcher from University of Hamburg. The author has contributed to research in topics: Adipose tissue & Lysosome. The author has an hindex of 16, co-authored 30 publications receiving 1076 citations. Previous affiliations of Jörg Heeren include Leibniz Institute for Neurobiology & Eppendorf (Germany).
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Journal ArticleDOI
Disturbed Cholesterol Traffic but Normal Proteolytic Function in LAMP-1/LAMP-2 Double-deficient Fibroblasts
Eeva-Liisa Eskelinen,Christine K. Schmidt,Silja Neu,Marion Willenborg,Graciela Fuertes,Natalia Salvador,Yoshitaka Tanaka,Renate Lüllmann-Rauch,Dieter Hartmann,Jörg Heeren,Kurt von Figura,Erwin Knecht,Paul Saftig +12 more
TL;DR: Findings indicate partially overlapping functions for LAMP-1 and -2 in lysosome biogenesis, autophagy, and cholesterol homeostasis as well as reduced amounts of lipid droplets in double deficient mice.
Journal ArticleDOI
Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
Antonella Carambia,Barbara Freund,Dorothee Schwinge,Oliver T. Bruns,Sunhild C. Salmen,Harald Ittrich,Rudolph Reimer,Markus Heine,Samuel Huber,Christian Waurisch,Alexander Eychmüller,David C. Wraith,Thomas Korn,Peter Nielsen,Horst Weller,Christoph Schramm,Stefan Lüth,Ansgar W. Lohse,Jörg Heeren,Johannes Herkel +19 more
TL;DR: These findings provide proof of principle that the selective delivery of autoantigen peptides to LSECs by NPs can induce antigen-specific Tregs and enable effective treatment of autoimmune disease.
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Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake.
Martin Merkel,Jörg Heeren,Wiebke Dudeck,Franz Rinninger,Herbert Radner,Jan L. Breslow,Ira J. Goldberg,Rudolf Zechner,Heiner Greten +8 more
TL;DR: In the presence of active LPL in the same tissue, inactive LPL augments triglyceride hydrolysis and increases whole particle triglyceride-rich lipoprotein and selective cholesterol ester uptake.
Journal ArticleDOI
Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice
Christian Baumeier,Daniel Kaiser,Jörg Heeren,Ludger Scheja,Clara John,Christoph Weise,Murat Eravci,Merit Lagerpusch,Gunnar Schulze,Hans-Georg Joost,Robert W. Schwenk,Annette Schürmann +11 more
TL;DR: Protection against diabetes upon caloric restriction and intermittent fasting associates with a modulation of lipid droplet protein composition and reduction of intracellular DAG species.
Journal ArticleDOI
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Elena Schmidt,Elena Schmidt,Ines Dhaouadi,Ines Dhaouadi,Isabella Gaziano,Isabella Gaziano,Matteo Oliverio,Matteo Oliverio,Paul Klemm,Paul Klemm,Motoharu Awazawa,Motoharu Awazawa,Gerfried Mitterer,Eduardo Fernandez-Rebollo,Eduardo Fernandez-Rebollo,Marta Pradas-Juni,Marta Pradas-Juni,Marta Pradas-Juni,Wolfgang Wagner,Philipp Hammerschmidt,Philipp Hammerschmidt,Rute Loureiro,Rute Loureiro,Rute Loureiro,Christoph A. Kiefer,Nils R. Hansmeier,Nils R. Hansmeier,Sajjad Khani,Sajjad Khani,Matteo Bergami,Markus Heine,Evgenia Ntini,Peter Frommolt,Peter Zentis,Ulf Andersson Ørom,Jörg Heeren,Matthias Blüher,Martin Bilban,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld +40 more
TL;DR: A maternally expressed, imprinted lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure is identified and it is demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper.