F
F. Ivy Carroll
Researcher at Research Triangle Park
Publications - 301
Citations - 11139
F. Ivy Carroll is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nicotinic agonist & Dopamine transporter. The author has an hindex of 52, co-authored 301 publications receiving 10411 citations. Previous affiliations of F. Ivy Carroll include RTI International & St. Joseph's Hospital and Medical Center.
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Journal ArticleDOI
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
Richard B. Rothman,Michael H. Baumann,Christina M. Dersch,Dana V. Romero,Kenner C. Rice,F. Ivy Carroll,John S. Partilla +6 more
TL;DR: In vitro methods determined the neurochemical mechanism of action of amphetamine, 3,4‐methylenedioxymethamphetamine (MDMA), (+)‐methamphetamine, ephedrine, phentermine, and aminorex, and demonstrated that the most potent effect of these stimulants is to release NE.
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Structure of the human κ-opioid receptor in complex with JDTic
Huixian Wu,Daniel Wacker,Mauro Mileni,Vsevolod Katritch,Gye Won Han,Eyal Vardy,Wei Liu,Aaron Thompson,Xi Ping Huang,F. Ivy Carroll,S. Wayne Mascarella,Richard B. Westkaemper,Philip D. Mosier,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens +15 more
TL;DR: Analysis of site-directed mutagenesis and ligand structure–activity relationships confirms the interactions observed in the crystal structure, thereby providing a molecular explanation for κ-OR subtype selectivity, and essential insights for the design of compounds with new pharmacological properties targeting the human λ-OR.
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Varenicline Is a Partial Agonist at α4β2 and a Full Agonist at α7 Neuronal Nicotinic Receptors
TL;DR: It is remarkable that varenicline is a potent, full agonist at α7 receptors with an EC50 of 18 ± 6 μM and an efficacy of 93 ± 7% (relative to acetylcholine).
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Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
TL;DR: Depression and stress are two states during cocaine abstinence which users identify as precipitating relapse, and JDTic may have properties which attenuate both.
Journal ArticleDOI
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Tao Che,Susruta Majumdar,Saheem A. Zaidi,Pauline W. Ondachi,John D. McCorvy,Sheng Wang,Philip D. Mosier,Rajendra Uprety,Eyal Vardy,Brian E. Krumm,Gye Won Han,Ming-Yue Lee,Els Pardon,Jan Steyaert,Xi Ping Huang,Ryan T. Strachan,Alexandra R. Tribo,Gavril W. Pasternak,F. Ivy Carroll,Raymond C. Stevens,Vadim Cherezov,Vsevolod Katritch,Daniel Wacker,Bryan L. Roth +23 more
TL;DR: A crystal structure of human KOP in complex with the potent epoxymorphinan opioid agonist MP1104 and an active-state-stabilizing nanobody is provided and key residues that propagate larger-scale structural rearrangements and transducer binding are illuminated that elucidate the structural determinants of KOP pharmacology, function, and biased signaling.