F
Fabien Conchonaud
Researcher at French Institute of Health and Medical Research
Publications - 10
Citations - 1281
Fabien Conchonaud is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Lipid raft & Fluorescence correlation spectroscopy. The author has an hindex of 9, co-authored 10 publications receiving 1207 citations. Previous affiliations of Fabien Conchonaud include Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork
Pierre-François Lenne,Pierre-François Lenne,L. Wawrezinieck,Fabien Conchonaud,Fabien Conchonaud,Olivier Wurtz,Olivier Wurtz,Annie Boned,Annie Boned,Xiao-Jun Guo,Hervé Rigneault,Hervé Rigneault,Hai-Tao He,Hai-Tao He,Didier Marguet,Didier Marguet +15 more
TL;DR: A free‐like diffusion was observed when both the lipid‐dependent and cytoskeleton‐based organizations were disrupted, which suggests that these are two main compartmentalizing forces at work in the plasma membrane.
Journal ArticleDOI
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
Rémi Lasserre,Xiao-Jun Guo,Fabien Conchonaud,Fabien Conchonaud,Yannick Hamon,Yannick Hamon,Omar Hawchar,Omar Hawchar,Anne-Marie Bernard,Anne-Marie Bernard,Saïdi M. Soudja,Saïdi M. Soudja,Pierre-François Lenne,Pierre-François Lenne,Hervé Rigneault,Hervé Rigneault,Daniel Olive,Georges Bismuth,Georges Bismuth,Jacques A. Nunès,Bernard Payrastre,Bernard Payrastre,Didier Marguet,Didier Marguet,Hai-Tao He,Hai-Tao He +25 more
TL;DR: It is reported here that highly dynamic nanodomains exist in both the outer and inner leaflets of the plasma membrane and it is demonstrated that rafts are critically involved in the activation of a signaling axis that is essential for cell physiology.
Journal ArticleDOI
Palmitoylation is required for efficient Fas cell death signaling
Krittalak Chakrabandhu,Zoltán Hérincs,Sébastien Huault,Britta Dost,Ling Peng,Fabien Conchonaud,Fabien Conchonaud,Didier Marguet,Didier Marguet,Hai-Tao He,Hai-Tao He,Anne-Odile Hueber +11 more
TL;DR: It is reported that the post‐translational modification of Fas by palmitoylation at the membrane proximal cysteine residue in the cytoplasmic region is the targeting signal for Fas localization to lipid rafts, as demonstrated in both cell‐free and living cell systems.
Journal ArticleDOI
Diffusion analysis within single nanometric apertures reveals the ultrafine cell membrane organization.
Jérôme Wenger,Fabien Conchonaud,Fabien Conchonaud,José Dintinger,L. Wawrezinieck,Thomas W. Ebbesen,Hervé Rigneault,Hervé Rigneault,Didier Marguet,Didier Marguet,Pierre-François Lenne,Pierre-François Lenne +11 more
TL;DR: A new methodology to probe the plasma membrane organization of living cells at the nanometric scale by performing fluorescence correlation spectroscopy with increasing aperture sizes and extracting information on the diffusion process from the whole set of data is described.
Journal ArticleDOI
Fas ligand is localized to membrane rafts, where it displays increased cell death–inducing activity
Nathalie Cahuzac,Wiebke Baum,Vladimir Kirkin,Fabien Conchonaud,L. Wawrezinieck,Didier Marguet,Ottmar Janssen,Martin Zörnig,Anne-Odile Hueber +8 more
TL;DR: It is concluded that FasL is recruited into lipid rafts for maximum Fas receptor contact and cell death-inducing potency, raising the possibility that certain pathologic conditions may be treated by altering the cellDeath-inducing capability of FasL with drugs affecting its raft localization.