F
Fabio Benfenati
Researcher at Istituto Italiano di Tecnologia
Publications - 424
Citations - 24243
Fabio Benfenati is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Synapsin & Synapsin I. The author has an hindex of 77, co-authored 406 publications receiving 21422 citations. Previous affiliations of Fabio Benfenati include University of Padua & University of Modena and Reggio Emilia.
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Journal ArticleDOI
Anti-synapsin monoclonal antibodies: epitope mapping and inhibitory effects on phosphorylation and Grb2 binding.
Paola Vaccaro,Luciana Dente,Franco Onofri,Adriana Zucconi,Sabrina Martinelli,Flavia Valtorta,Paul Greengard,Gianni Cesareni,Fabio Benfenati +8 more
TL;DR: The epitopes of a panel of monoclonal antibodies raised against synapsin I and II are localized and their ability to interfere with the interactions of the synapsins with protein kinases, actin and Src homology-3 (SH3) domains is characterized.
Journal ArticleDOI
Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I.
Maila Giannandrea,Fabrizia C. Guarnieri,Niels H. Gehring,Elena Monzani,Fabio Benfenati,Fabio Benfenati,Andreas E. Kulozik,Flavia Valtorta +7 more
TL;DR: Data indicate that in patients carrying the W356× mutation the function of synapsin I is markedly impaired, due to both the strongly decreased translation and the altered function of the NMD-escaped protein, and support the value of Syn1−/− mice as an experimental model mimicking the human pathology.
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Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength
Anna Rocchi,Daniela Moretti,Gabriele Lignani,Gabriele Lignani,Gabriele Lignani,Elisabetta Colombo,Joachim Scholz-Starke,Pietro Baldelli,Tatiana Tkatch,Fabio Benfenati +9 more
TL;DR: The data demonstrate that miR-218 may play a key role in the regulation of AMPA-mediated excitatory transmission and in the homeostatic regulation of synaptic plasticity.
Journal ArticleDOI
Octopus arm regeneration: Role of acetylcholinesterase during morphological modification ☆
TL;DR: It is suggested that AChE protein may have an important influence in the process of regeneration and that it could be considered as a potential target to promote or regulate the regenerative process.
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2-Deoxy-d-glucose enhances tonic inhibition through the neurosteroid-mediated activation of extrasynaptic GABAA receptors.
Nicola Forte,Nicola Forte,Lucian Medrihan,Beatrice Cappetti,Pietro Baldelli,Pietro Baldelli,Fabio Benfenati,Fabio Benfenati +7 more
TL;DR: The ability of 2‐deoxy‐d‐glucose (2‐DG), a glucose analog that inhibits glycolytic enzymes, of potentiating γ‐aminobutyric acid (GABA)ergic tonic inhibition via neurosteroid‐mediated activation of extrasynaptic GABAA receptors is reported.