Fabio Benfenati

TL;DR: The reversible interactions between synapsin I and SV are highly regulated by site‐specific phosphorylation and have kinetics of the same order of magnitude as the kinetics in mammalian neurons under comparable temperature conditions, consistent with the hypothesis that synapsIn I associates with, and dissociates from, SV during the exo–endocytotic cycle.

TL;DR: Functional and expression studies demonstrate impaired lysosomal homeostasis, defective neurite elongation and loss of excitatory inputs in cultured neurons.

TL;DR: The study of PRRT2 and of its mutations may help in refining knowledge of the process of synaptic transmission and elucidating the pathogenetic mechanisms leading to derangement of network function in paroxysmal disorders.

TL;DR: Data indicate that phosphorylation ofsynapsin domain A is essential for the synapsin-induced enhancement of neurotransmitter release and suggest that endogenous kinases phosphorylating this domain play a central role in the regulation of the efficiency of the exocytotic machinery.

TL;DR: It is demonstrated that in neurons loaded with the Ziapin2 compound, millisecond pulses of visible light induce a transient hyperpolarization followed by a delayed depolarization that triggers action potential firing and these effects are persistent and can be evoked in vivo up to 7 days, proving the potential of ZiAPin2 for the modulation of membrane capacitance in the millisecond timescale.