F
Fabio Benfenati
Researcher at Istituto Italiano di Tecnologia
Publications - 424
Citations - 24243
Fabio Benfenati is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Synapsin & Synapsin I. The author has an hindex of 77, co-authored 406 publications receiving 21422 citations. Previous affiliations of Fabio Benfenati include University of Padua & University of Modena and Reggio Emilia.
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Journal ArticleDOI
Study of the conformation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by fluorescence spectroscopy.
TL;DR: Findings indicate that DARPP-32 contains at least two distinct domains and that phosphorylation has no dramatic effects on its conformation.
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Biocompatibility of a Magnetic Tunnel Junction Sensor Array for the Detection of Neuronal Signals in Culture
Daniela Moretti,Mattia L. DiFrancesco,Parikshit Pratim Sharma,Silvia Dante,Edoardo Albisetti,Marco Monticelli,Riccardo Bertacco,Daniela Petti,Pietro Baldelli,Pietro Baldelli,Fabio Benfenati +10 more
TL;DR: This study presents the first biomagnetic chip based on magnetic tunnel junction (MTJ) technology for cell culture studies and shows the biocompatibility of these sensors, paving the way to the development of high performing biomagnetic sensing technology for the electrophysiology of in vitro systems, in analogy with Multi Electrode Arrays.
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Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses.
Martina Chiacchiaretta,Shahrzad Latifi,Mattia Bramini,Manuela Fadda,Anna Fassio,Fabio Benfenati,Fabrizia Cesca +6 more
TL;DR: A novel extracellular pH-indicator that is sensitive to acidic shifts reveals that neuronal hyperactivity causes acidic shifts that are localized to active synapses and generated by the Na+/H+ exchanger.
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TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons.
Davide Aprile,Floriana Fruscione,Simona Baldassari,Manuela Fadda,Daniele Ferrante,Antonio Falace,Emmanuelle Buhler,Jacopo Sartorelli,Alfonso Represa,Pietro Baldelli,Fabio Benfenati,Federico Zara,Anna Fassio,Anna Fassio +13 more
TL;DR: The data reveal that alterations of membrane trafficking at the growth cone induced by TBC1D24 loss of function cause axonal and excitability defects, which correlate with the disease severity and highlight an important role for TBC 1D24 in connectivity during brain development.
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Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.
Marco Milanese,Tiziana Bonifacino,Ernesto Fedele,Claudia Rebosio,Luca Cattaneo,Fabio Benfenati,Cesare Usai,Giambattista Bonanno +7 more
TL;DR: It can be hypothesized that the excessive GAT-1 and GlyT-1/2 heterotransporter-mediated Glu release, in the spinal cord of SOD1(G93A) mice, is due to the heterotranporter over-expression at the nerve terminal membrane, promoted by thecessive Glu exocytosis.