F
Fabio Benfenati
Researcher at Istituto Italiano di Tecnologia
Publications - 424
Citations - 24243
Fabio Benfenati is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Synapsin & Synapsin I. The author has an hindex of 77, co-authored 406 publications receiving 21422 citations. Previous affiliations of Fabio Benfenati include University of Padua & University of Modena and Reggio Emilia.
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Journal ArticleDOI
A Push–Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels
V. Valente,Antonella Marte,Francesca Franchi,Bruno Sterlini,Silvia Casagrande,Anna Corradi,Pietro Baldelli,Fabio Benfenati +7 more
TL;DR: In this article , it was shown that β-subunits and PRRT2 do not interact with each other and act as independent non-competitive modulators of Na V 1.2/NaV 1.6 channels, without affecting resurgent current.
in Familial Infantile Myoclonic Epilepsy
Antonio Falace,Fabia Filipello,Veronica La Padula,Nicola Vanni,Francesca Madia,Davide De Pietri Tonelli,Fabrizio A. de Falco,Pasquale Striano,Franca Dagna Bricarelli,Carlo Minetti,Fabio Benfenati,Anna Fassio,Federico Zara +12 more
TL;DR: A gene mutation involved in autosomal-recessive idiopathic epilepsy is identified, the involvement of ARF6-dependent molecular pathway in brain hyperexcitability and seizures is unveiled, and the emerging role of subtle cytoarchitectural alterations in the etiology of this group of common epileptic disorders is confirmed.
Journal ArticleDOI
The different clinical facets of SYN1-related neurodevelopmental disorders
Ilaria Parenti,Elsa Leitão,Alma Kuechler,Laurent Villard,Cyril Goizet,Cécile Courdier,Allan Bayat,Alessandra Rossi,Sophie Julia,Ange-Line Bruel,Frédéric Tran Mau-Them,Sophie Nambot,Daphné Lehalle,Marjolaine Willems,James Lespinasse,Jamal Ghoumid,Roseline Caumes,Thomas Smol,Salima El Chehadeh,Elise Schaefer,Marie-Thérèse Abi-Warde,Boris Keren,Alexandra Afenjar,Anne-Claude Tabet,Jonathan Levy,Anna Maruani,Ángel Aledo-Serrano,Waltraud Garming,C. Milleret-Pignot,Anna Chassevent,Marije Koopmans,Nienke E. Verbeek,Richard A. Person,Rebecca S Belles,Gary A. Bellus,Bonnie A. Salbert,Frank J. Kaiser,Laure Mazzola,Philippe Convers,Laurine Perrin,Amélie Piton,Gert Wiegand,Andrea Accogli,Francesco Brancati,Fabio Benfenati,Nicolas Chatron,David Lewis-Smith,Rhys H. Thomas,Federico Zara,Pasquale Striano,Gaetan Lesca,Christel Depienne +51 more
TL;DR: In this paper , a clinical and molecular spectrum of the SYN1-related neurodevelopmental disorders was described by describing 31 novel individuals harboring 22 different variants, including truncating variants, non-truncating variants and in-frame duplications.
Journal ArticleDOI
Synapsin III Controls Early Phases of Dopaminergic Neurons Development in Fishes and Mammals by Acting Upstream of BDNF and Cdk5 Signaling
Gaia Faustini,Francesca Longhena,Alessia Muscò,Federica Bono,Edoardo Parrella,Luca La Via,Alessandro Barbon,Marina Pizzi,Franco Onofri,Fabio Benfenati,Cristina Missale,Maurizio Memo,Daniela Zizioli,Arianna Bellucci,Sneak Peek Administrator +14 more
TL;DR: It is disclosed that Syn III governs early mDN developmental stages in fishes and mammals through the upstream control of brain derived neurotrophic factor (BDNF)-mediated and cAMP-dependent protein kinase 5 (Cdk5)-stimulated dendrite development.
Coupling Shape GABA-Evoked Currents Binding Sites, Singly Bound States, and Conformation
Jerzy W. Mozrzymas,Andrea Barberis,Katarzyna Mercik,Fabio Benfenati,Enrica Maria Petrini,Thierry Nieus,Tiziana Ravasenga,Stefania Guazzi,Marcin Szczot,M. Kisiel,Marta M. Czyzewska,Marcel P. Goldschen-Ohm,Alexander Haroldson,Mathew V. Jones,Robert A. Pearce +14 more
TL;DR: GABA receptors A GABA A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAergic Responses A Influence of GABA.