Fabio Benfenati

TL;DR: The ability to bind multiple SH3 domains further implicates the synapsins in signal transduction and protein-protein interactions at the nerve terminal level.

TL;DR: It is demonstrated that Src-mediated tyrosine phosphorylation ofsynapsin I increases its binding to SVs and actin, and increases the formation of synapsin dimers, which are both potentially involved in SV clustering.

TL;DR: Higher rates of proliferation are observed for the two neuronal cell types, the mouse neuroblastoma cells (N2A) and the immortalized human cortical neuronal cells (HCN1A), speculated that the higher adhesion on MeP1 could be attributed to a preferential matching of the substrate topography with the recently observed multiscale molecular architecture of focal adhesions.

TL;DR: A laser scanning two-photon microscope with remote and motionless control of the focus position bypasses the limitations of microscopes based on moving objectives, enabling high-resolution inertia-free 3D imaging.

TL;DR: This work has identified Kidins220 as a main player in the modulation of neurotrophin and vascular endothelial growth factor signaling in vivo, and a primary determinant for neuronal and cardiovascular development, and demonstrates that Kidins 220 constitutively interacts with VEGFR2.