C
Christian Bjerggaard Vaegter
Researcher at Aarhus University
Publications - 54
Citations - 2652
Christian Bjerggaard Vaegter is an academic researcher from Aarhus University. The author has contributed to research in topics: Neurotrophic factors & Receptor. The author has an hindex of 21, co-authored 48 publications receiving 2067 citations. Previous affiliations of Christian Bjerggaard Vaegter include Lundbeck & University of Copenhagen.
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Journal ArticleDOI
Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
Fenghua Hu,Thihan Padukkavidana,Christian Bjerggaard Vaegter,Owen A. Brady,Yanqiu Zheng,Ian R. A. Mackenzie,Howard Feldman,Anders Nykjaer,Stephen M. Strittmatter +8 more
TL;DR: The 50% PGRN decrease causative in FTLD-TDP cases is mimicked in GRN+/⁻ mice, and is fully normalized by Sort1 ablation, suggesting Sortilin-mediated PGRn endocytosis is likely to play a central role in FT LD-T DP pathophysiology.
Journal ArticleDOI
Calmodulin Kinase II Interacts with the Dopamine Transporter C Terminus to Regulate Amphetamine-Induced Reverse Transport
Jacob U. Fog,Habibeh Khoshbouei,Marion Holy,William A. Owens,Christian Bjerggaard Vaegter,Namita Sen,Yelyzaveta A. Nikandrova,Erica Bowton,Douglas G. McMahon,Roger J. Colbran,Lynette C. Daws,Harald H. Sitte,Jonathan A. Javitch,Aurelio Galli,Ulrik Gether +14 more
TL;DR: The data suggest that CaMKIIalpha binding to the DAT C terminus facilitates phosphorylation of the D AT N terminus and mediates amphetamine-induced dopamine efflux.
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Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS
Line S. Reinert,Katarína Lopušná,Katarína Lopušná,Henriette Winther,Chenglong Sun,Martin K. Thomsen,Ramya Nandakumar,Trine H. Mogensen,Trine H. Mogensen,Morten Meyer,Christian Bjerggaard Vaegter,Jens R. Nyengaard,Katherine A. Fitzgerald,Søren R. Paludan +13 more
TL;DR: Sensing of HSV-1 infection in the CNS by microglia through the cGAS–STING pathway orchestrates an antiviral program that includes type I IFNs and immune-priming of other cell types.
Journal ArticleDOI
Schwann cell interactions with axons and microvessels in diabetic neuropathy
Nádia Gonçalves,Christian Bjerggaard Vaegter,Henning Andersen,Leif Østergaard,Nigel A. Calcutt,Troels S. Jensen +5 more
TL;DR: The evolving concept of Schwannopathy as an integral factor in the pathogenesis of diabetic neuropathy is discussed, and how disruption of the interactions between Schwann cells, axons and microvessels contribute to the disease is discussed.
Journal ArticleDOI
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Christian Bjerggaard Vaegter,Pernille Jansen,Anja W. Fjorback,Simon Glerup,Sune Skeldal,Mads Kjolby,Mette Richner,Bettina Erdmann,Jens R. Nyengaard,Lino Tessarollo,Gary R. Lewin,Thomas E. Willnow,Moses V. Chao,Anders Nykjaer +13 more
TL;DR: It is shown that the sorting receptorsortilin interacts with TrkA, TrkB and TrkC and enables their anterograde axonal transport, thereby enhancing neurotrophin signaling and demonstrating a role for sortilin as an anterOGrade trafficking receptor for Trk and a positive modulator of neurotrophIn-induced neuronal survival.