F
Filip K. Knop
Researcher at University of Copenhagen
Publications - 523
Citations - 17834
Filip K. Knop is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 61, co-authored 437 publications receiving 13614 citations. Previous affiliations of Filip K. Knop include Copenhagen University Hospital & Victor Chang Cardiac Research Institute.
Papers
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Journal ArticleDOI
Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts.
Yuki M.F. Andersen,Alexander Egeberg,Lu Ban,Lu Ban,S. Gran,Hywel C Williams,Nick A Francis,Filip K. Knop,Gunnar Gislason,Lone Skov,Jacob P. Thyssen +10 more
TL;DR: A positive association between topical CS prescribing and incident T2D in Danish and U.K. adult populations is found, and Clinicians should be cognizant of possible diabetogenic effects of potent topical CSs.
Book ChapterDOI
Incretin-Based Therapy and Type 2 Diabetes
Kristine J. Hare,Filip K. Knop +1 more
TL;DR: This chapter focuses on the incretin hormones, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP), and their therapeutic potential in treating patients with type 2 diabetes, and outlines the scientific basis for the development of incretIn mimetics and incret in enhancers.
Journal ArticleDOI
Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment.
Christoffer A. Hagemann,Chen Zhang,Henrik H. Hansen,Tina Jorsal,Kristoffer T.G. Rigbolt,Martin R. Madsen,Natasha C. Bergmann,Sebastian M. Nguyen Heimbürger,Sebastian M. Nguyen Heimbürger,Mechthilde Falkenhahn,Stefan Theis,Kristin Breitschopf,Stephanie Holm,Morten Hedegaard,Mikkel B. Christensen,Tina Vilsbøll,Tina Vilsbøll,Birgitte Holst,Niels Vrang,Jacob Jelsing,Filip K. Knop +20 more
TL;DR: To identify novel gut-derived peptides with therapeutic potential in obesity and/or diabetes by profiling of EEC-specific molecular changes in obese patients following RYGB-induced weight loss, small intestinal LEAP2 expression was upregulated after RY GB.
Journal ArticleDOI
Postpartum reversibility of impaired incretin effect in gestational diabetes mellitus.
Marcin Kosiński,Filip K. Knop,Louise Vedtofte,J. Grycewiczv,P. Swierzewska,Katarzyna Cypryk,Tina Vilsbøll +6 more
TL;DR: It is suggested that decreased incretin effect in women with GDM is a fully reversible phenomenon which is fully reversible alongside the restoration of normal glucose homeostasis, whereas the reduction in incretIn effect during pregnancy in Women with NGT was insignificant.
Journal ArticleDOI
Alpha- and beta-cell abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes
Salvatore Calanna,Roberto Scicali,Antonino Di Pino,Filip K. Knop,Salvatore Piro,Agata Maria Rabuazzo,Francesco Purrello +6 more
TL;DR: Findings show clear alpha- and beta-cell dysfunction in HbA1c-defined type 2 diabetes compatible with the previously described pathophysiology of plasma glucose-definedtype 2 diabetes and defective insulin response in combination with inappropriate suppression of glucagon, which may constitute new targets for pharmacological interventions.