F
Filip K. Knop
Researcher at University of Copenhagen
Publications - 523
Citations - 17834
Filip K. Knop is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 61, co-authored 437 publications receiving 13614 citations. Previous affiliations of Filip K. Knop include Copenhagen University Hospital & Victor Chang Cardiac Research Institute.
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Journal ArticleDOI
Current evidence for a role of GLP‐1 in Roux‐en‐Y gastric bypass‐induced remission of type 2 diabetes
TL;DR: This article critically evaluates the current evidence for a role of GLP‐1 in RYGB‐induced remission of T2DM and concludes that the former is likely to be a key mediator in the latter.
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KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes.
Kasper Aaboe,Filip K. Knop,Tina Vilsbøll,Aage Vølund,Ulf Simonsen,Carolyn F. Deacon,Sten Madsbad,Jens J. Holst,Thure Krarup +8 more
TL;DR: It is demonstrated that inhibiting the K(ATP) channels of the diabetic beta-cell acutely using SU significantly increases both the peripheral insulin response to GIP and GIP-induced insulin secretion, indicating an ameliorated insulinotropic effect of GIP.
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Incretin-Based Therapy of Type 2 Diabetes Mellitus
TL;DR: Two new drug classes based on the actions of the incretin hormones have recently been approved for therapy of T2DM; injectable long-acting stable analogues of GLP-1, incret in mimetics, and orally available inhibitors of dipeptidyl peptidase 4 (DPP4; the enzyme responsible for the rapid degradation of GLp-1 and GIP), the so-called incretIn enhancers.
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L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Mari L. Lund,Giovanni Sorrentino,Kristoffer L. Egerod,Chantal Kroone,Brynjulf Mortensen,Filip K. Knop,Frank Reimann,Fiona M. Gribble,Daniel J. Drucker,Eelco J.P. de Koning,Eelco J.P. de Koning,Kristina Schoonjans,Fredrik Bäckhed,Fredrik Bäckhed,Thue W. Schwartz,Natalia Petersen +15 more
TL;DR: G-protein–coupled bile acid receptor 1 (GPBAR1) is identified as a selective regulator of intestinal L-cell differentiation through a paracrine GLP-1–dependent and serotonin-mediated mechanism.
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Incretin Effect and Glucagon Responses to Oral and Intravenous Glucose in Patients With Maturity-Onset Diabetes of the Young—Type 2 and Type 3
Signe Harring Østoft,Jonatan I. Bagger,Torben Hansen,Oluf Pedersen,Jens J. Holst,Filip K. Knop,Tina Vilsbøll +6 more
TL;DR: HNF1A-diabetes, similar to type 2 diabetes, is characterized by an impaired incretin effect and inappropriate glucagon responses, whereas incretIn effect and glucagon response to oral glucose remain unaffected in GCK-di diabetes, reflecting important pathogenetic differences between the two MODY forms.