F
Florentina Wirjatijasa
Researcher at Goethe University Frankfurt
Publications - 4
Citations - 460
Florentina Wirjatijasa is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Neuroprotection & Transforming growth factor. The author has an hindex of 4, co-authored 4 publications receiving 433 citations.
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Journal ArticleDOI
Genome-wide association study of intracranial aneurysm identifies three new risk loci
Katsuhito Yasuno,Kaya Bilguvar,Philippe Bijlenga,Siew-Kee Low,Boris Krischek,Georg Auburger,Matthias Simon,Dietmar Krex,Zulfikar Arlier,Nikhil R. Nayak,Ynte M. Ruigrok,Mika Niemelä,Atsushi Tajima,Mikael von und zu Fraunberg,Tamás Dóczi,Florentina Wirjatijasa,Akira Hata,Jordi Blasco,Ági Oszvald,Hidetoshi Kasuya,Gulam Zilani,Beate Schoch,Pankaj Singh,Pankaj Singh,Carsten Stüer,Roelof Risselada,Jürgen Beck,Teresa Sola,Filomena Ricciardi,Arpo Aromaa,Thomas Illig,Stefan Schreiber,Cornelia M. van Duijn,Leonard H. van den Berg,Claire Perret,Carole Proust,Constantin Roder,Ali K. Ozturk,Emilia I. Gaal,Daniela Berg,Christof Geisen,Christoph M. Friedrich,Paul Summers,Alejandro F. Frangi,Alejandro F. Frangi,Matthew W. State,H.-Erich Wichmann,Monique M.B. Breteler,Cisca Wijmenga,Shrikant Mane,Leena Peltonen,Leena Peltonen,Vivas Elio,Miriam C. J. M. Sturkenboom,Patricia V. Lawford,James V. Byrne,Juan Macho,Erol I. Sandalcioglu,Bernhard Meyer,Andreas Raabe,Helmuth Steinmetz,Daniel A. Rüfenacht,Juha E. Jääskeläinen,Juha Hernesniemi,Gabriel J.E. Rinkel,Hitoshi Zembutsu,Ituro Inoue,Aarno Palotie,Aarno Palotie,François Cambien,Yusuke Nakamura,Richard P. Lifton,Murat Gunel +72 more
TL;DR: Two new loci showing strong evidence for association with intracranial aneurysms are identified and several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair.
Journal ArticleDOI
Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures.
Nils P. Hailer,Florentina Wirjatijasa,Nadine Roser,Gunnar T. R. Hischebeth,Horst-Werner Korf,Faramarz Dehghani +5 more
TL;DR: Findings show that hitherto unidentified astrocyte‐derived factors that are probably not identical with TGF‐β can substantially enhance neuronal survival, either by eliciting direct neuroprotective effects or by modulating the microglial response to neuronal injury.
Journal ArticleDOI
Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells.
TL;DR: It is demonstrated that IL‐4, IL‐10, and IL‐1‐ra induce microglial ramification and reduce ICAM‐ 1‐expression, whereas the secretion of proinflammatory cytokines is not prevented, and unidentified astrocytic factors that are not identical with IL‐ 4, IL-10, or TGF‐β possess strong immunomodulatory properties.
Journal ArticleDOI
The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures.
Faramarz Dehghani,Gunnar T. R. Hischebeth,Florentina Wirjatijasa,Angelika Kohl,Horst-Werner Korf,Nils P. Hailer +5 more
TL;DR: In conclusion, MMF inhibits proliferation and activation of microglia and astrocytes and protects neurons after excitotoxic injury.