F
Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery
Eric M. Graham,Andrew M. Atz,Jenna F Gillis,Stacia M. DeSantis,A Lauren Haney,Rachael L. Deardorff,Walter E. Uber,Scott Reeves,Francis X. McGowan,Scott M. Bradley,Francis G. Spinale +10 more
TL;DR: Aprotinin, compared with tranexamic acid, was associated with reduced perioperative blood product use, improved early indices of postoperative recovery, and attenuated indices of cytokine activation, without early adverse effects.
Journal ArticleDOI
Temporally and regionally disparate differences in plasmin activity by tranexamic acid.
Daryl L. Reust,Scott Reeves,James H. Abernathy,Jennifer A. Dixon,William F. Gaillard,Rupak Mukherjee,Christine N. Koval,Robert E. Stroud,Francis G. Spinale,Francis G. Spinale +9 more
TL;DR: Using a large animal model and in vivo microdialysis measurements of PLact, the unique findings from this study were 2-fold; TXA induced temporally distinct PLact profiles within the plasma and selected interstitial compartments and caused region-specific changes inPLact profiles.
Journal ArticleDOI
Assessment of right ventricular contractile performance after pulmonary resection
TL;DR: Depressed RV contractility does not appear to play a predominant role in this early postoperative period, and isochronal RVEDVI and RVSWI values were within the confidence limits of the preload recruitable stroke work relation.
Journal Article
Retrograde versus antegrade cardioplegia : impact on right ventricular function. Discussion
E. C. Douville,John M. Kratz,Francis G. Spinale,Fred A. Crawford,Calvert C. Alpert,A. Pearce,R. E. Clark,N. J. Snow +7 more
TL;DR: Right ventricular parameters were equivalent in both groups at all time intervals except 30 minutes after bypass, indicating better right ventricular function with retrograde cardioplegia early after bypass.
Journal ArticleDOI
Thermodilution Right Ventricular Ejection Fraction: Catheter Positioning Effects
TL;DR: This study examined the effects of the thermistor position within the pulmonary artery and injectate site within the right atrium on RV thermodilution ejection fraction measurements and demonstrated that RV ejection fractions can be reliably obtained using thermodillution.