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Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
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Journal ArticleDOI
Targeted Regional Injection of Biocomposite Microspheres Alters Post–Myocardial Infarction Remodeling and Matrix Proteolytic Pathways
Jennifer A. Dixon,Robert C. Gorman,Robert E. Stroud,Rupak Mukherjee,Evan C. Meyer,Nathaniel L. Baker,Masato Morita,Hirotsugu Hamamoto,Liam P. Ryan,Joseph H. Gorman,Francis G. Spinale +10 more
TL;DR: Target injection of a biocomposite material can favorably affect the post-MI remodeling process and therefore holds promise as a treatment strategy in and of itself, or as a matrix with potentially synergistic effects with localized pharmacological or cellular therapies.
Journal ArticleDOI
Reperfused vs. nonreperfused myocardial infarction: when to use which model
Merry L. Lindsey,Merry L. Lindsey,Lisandra E. de Castro Brás,Kristine Y. DeLeon-Pennell,Kristine Y. DeLeon-Pennell,Nikolaos G. Frangogiannis,Ganesh V. Halade,Caitlin C. O'Meara,Francis G. Spinale,Zamaneh Kassiri,Jonathan A. Kirk,Petra Kleinbongard,Crystal M. Ripplinger,Keith R. Brunt +13 more
TL;DR: There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI as mentioned in this paper.
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Effects of aprotinin or tranexamic acid on proteolytic/cytokine profiles in infants after cardiac surgery.
Tain Yen Hsia,Tim C. McQuinn,Rupak Mukherjee,Rachael L. Deardorff,Jerry E. Squires,Robert E. Stroud,Fred A. Crawford,Scott M. Bradley,Scott Reeves,Francis G. Spinale,Francis G. Spinale +10 more
TL;DR: These unique findings demonstrated differential effects between the serine protease inhibitor aprotinin and the lysine analogue TXA with respect to cytokine and MMP induction in the early postoperative period.
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Brain blood flow patterns after the development of congestive heart failure: effects of treadmill exercise.
Caparas Sn,Mark J. Clair,R S Krombach,Jennifer W. Hendrick,Ward V. Houck,Scott B. Kribbs,Rupak Mukherjee,Tempel Ge,Francis G. Spinale +8 more
TL;DR: The development of pacing‐induced CHF was associated with diminished brain perfusion under resting conditions and with treadmill exercise, and these perfusion abnormalities were pronounced in specific regions of the brain.
Journal ArticleDOI
Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation
John R. Barbour,Robert E. Stroud,Abigail S. Lowry,Leslie L. Clark,Allyson M. Leone,Jeffery A. Jones,Francis G. Spinale,Francis G. Spinale,John S. Ikonomidis +8 more
TL;DR: These findings show 2 phases of matrix metalloproteinase abundance during murine thoracic aortic aneurysm formation, and the late tissue inhibitor of metaloproteinases 4 increase might explain prevention of further aorti dilation past 4 weeks.