F
Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
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Journal ArticleDOI
Bioactive Peptide Signaling Within the Myocardial Interstitium and the Matrix Metalloproteinases
TL;DR: The results from this study emphasize the fact that the biologically active molecules that are contained within the myocardial interstitium do not act independently, but instead, a summation of signaling events ultimately determines the structure and function of the ECM.
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The Effects of Regular Exercise on Circulating Cardiovascular-related MicroRNAs.
Jacob L. Barber,Kia N. Zellars,Kurt G. Barringhaus,Claude Bouchard,Francis G. Spinale,Mark A. Sarzynski +5 more
TL;DR: Examination of 20 previously sedentary adults from the HERITAGE Family Study who completed 20 weeks of endurance exercise training provided further evidence of the effects of regular exercise on the circulating miRNA profile.
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Differential effects of calcium channel antagonists in the amelioration of radial artery vasospasm.
Brian R. Bond,James L. Zellner,B.Hugh Dorman,Marlina M. Multani,John M. Kratz,Arthur J. Crumbley,Fred A. Crawford,Francis G. Spinale +7 more
TL;DR: These results demonstrate that neurohormonal factors released post-CABG can cause RA vasoconstriction, and that calcium channel antagonists are not equally effective in abrogating that response.
Journal ArticleDOI
Alterations in the myocardial capillary vasculature accompany tachycardia-induced cardiomyopathy.
TL;DR: Chronic SVT caused significant remodeling of the capillary vasculature; these changes were associated with reduced MBF, myocyte injury, and LV dysfunction.
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Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis.
Michael R. Zile,Catalin F. Baicu,Robert E. Stroud,An O. Van Laer,Jazmine E. Arroyo,Rupak Mukherjee,Jeffrey A. Jones,Francis G. Spinale +7 more
TL;DR: The hypothesis that membrane type 1-matrix metalloproteinase (MT1-MMP) is directly induced at the transcriptional level in vivo during PO and is related to changes in LV collagen content is tested and supports the concept that certain proteases play a pivotal role in PO-induced matrix remodeling and fibrosis.