F
Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
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DAPI as a Useful Stain for Nuclear Quantitation
TL;DR: A simple-to-use fluorescent stain, 4',6-diamidino-2-phenylindole (DAPI), visualizes nuclear DNA in both living and fixed cells and shows no ultrastructural changes compared to the appearance of cells not stained with DAPI.
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L-type calcium channel abundance and function with cardiac hypertrophy and failure: a review.
TL;DR: Alterations inl-type Ca2+ channel function with end-stage human CHF remain equivocal andbeta-adrenergic receptor mediated augmentation of L-typeCa2+ currents has been demonstrated to be reduced, in general, with hypertrophy and CHF.
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Effects of Age on Plasma Matrix Metalloproteinases (MMPs) and Tissue Inhibitor of Metalloproteinases (TIMPs)
D. Dirk Bonnema,Carson S. Webb,Weems R. Pennington,Robert E. Stroud,Amy E. Leonardi,Leslie L. Clark,Catherine D. McClure,Laura Finklea,Francis G. Spinale,Michael R. Zile +9 more
TL;DR: MMPs and TIMPs changed as a function of age in the absence of clinically significant cardiovascular disease and were associated with concentric remodeling and decreased LV diastolic function.
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Myocardial and interstitial matrix metalloproteinase activity after acute myocardial infarction in pigs
Takuma Etoh,Cassandra Joffs,Anne M. Deschamps,Jennifer Davis,Kathryn B. Dowdy,Jennifer W. Hendrick,Simona C. Baicu,Rupak Mukherjee,Marlina Manhaini,Francis G. Spinale +9 more
TL;DR: It is demonstrated that myocardial MMP activation can occur within the MI region in the absence of reperfusion and suggested that MMP release and activation occurs within the ischemic myocardia interstitium in the early post-MI period.
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Chronic supraventricular tachycardia causes ventricular dysfunction and subendocardial injury in swine.
Francis G. Spinale,D. A. Hendrick,Fred A. Crawford,Alison C. Smith,Y. Hamada,Blase A. Carabello +5 more
TL;DR: Chronic supraventricular tachycardia resulted in severe biventricular pump dysfunction and chamber dilatation that were associated with ultrastructural alterations and reduced enzyme activity of the subendocardial myocytes, which resulted in a reduction in left ventricular wall thickness compared with 14 control animals.