Francis G. Spinale

TL;DR: The conduct of and evaluation for cardiac transplantation has been well described previously and therefore will not be evaluated, but there has been recent progress in the genetic modification of animal organs for potential use in transplantation (xenografts) and if these developments come to fruition, then cardiac transplant/organ replacement may become a surgical option for a much greater number of CHF patients.

TL;DR: Because MMPs can degrade the extracellular matrix, leading to increased vascular permeability, attenuation of M MPs may have decreased the local tissue injury known to occur as a result of these enzymes; future prospective studies to test this hypothesis directly are warranted.

TL;DR: Concentration-dependent protective effects of adenosine-augmented cardioplegia on myocyte contractile function with subsequent reperfusion and rewarming are demonstrated and suggest that stimulation of putative myocyte adenosines receptors may provide enhanced protective effects on myocytes contractile processes during cardioleongic arrest.

TL;DR: It is found that serial profiling a large array of cytokines and proteolytic enzymes after surgery for congenital heart disease can provide insight into relationships between changes in bioactive molecules to early postoperative outcomes.

TL;DR: The present study demonstrated for the first time that a load-dependent relationship can be derived for intact isolated LV myocytes in both normal and CHF states and identified the defect in the capacity of SVT-CHF myocytes to respond to an increased relative resistive load.