F
Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
Papers
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Journal ArticleDOI
Determinants of extracellular matrix remodelling are differentially expressed in paediatric and adult dilated cardiomyopathy.
Tain-Yen Hsia,Jeremy M. Ringewald,Jeremy M. Ringewald,Robert E. Stroud,Robert E. Stroud,Geoffrey A. Forbus,Geoffrey A. Forbus,Scott M. Bradley,Scott M. Bradley,Wendy K. Chung,Francis G. Spinale,Francis G. Spinale +11 more
TL;DR: This study tested the hypothesis that different MMP/TIMP profiles occur in paediatric and adult DCM patients.
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The direct effects of propofol on myocyte contractile function after hypothermic cardioplegic arrest.
TL;DR: Results from the present study demonstrated for the first time that the reduction in isolated myocyte contractile function after simulated HHCA is further decreased by propofol administration.
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Localized targeting of biomaterials following myocardial infarction: a foundation to build on.
James A Shuman,Jonathan Zurcher,Ashley A. Sapp,Jason A. Burdick,Robert C. Gorman,Joseph H. Gorman,Edie C. Goldsmith,Francis G. Spinale,Francis G. Spinale +8 more
TL;DR: Significant changes in local cell and interstitial biology within the targeted MI region can occur following injection of certain biomaterials, which may hold important considerations when using these materials as matrices for adjuvant drug/cell therapies.
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Cell–Matrix Signaling and Thrombospondin Another Link to Myocardial Matrix Remodeling
TL;DR: A potential role of myocardial TSP-2 in the adaptive and maladaptive remodeling that occurs in left ventricular hypertrophy (LVH) is reported and a brief review of the biology of TSP with respect to matrix signaling and remodeling is presented.
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Myosin heavy chain synthesis during the progression of chronic tachycardia induced heart failure in rabbits.
TL;DR: It is demonstrated that a contributory mechanism for the LV remodeling and lack of myocardial growth, which occurs with VT induced heart failure, is enhanced contractile protein degradative processes.