F
Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
Papers
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Journal ArticleDOI
Protein Kinase C Isoform Activation and Endothelin-1 Mediated Defects in Myocyte Contractility After Cardioplegic Arrest and Reperfusion
Rupak Mukherjee,Kimberly A. Apple,Christina E. Squires,Brooke S. Kaplan,Julie E. McLean,Stuart M. Saunders,Robert E. Stroud,Francis G. Spinale +7 more
TL;DR: Inhibition of the classical PKC isoforms relieved the negative inotropic and lusitropic effects of ET-1 after CA and provides mechanistic support for developing targeted inhibitory strategies with respect toET-1 signaling and myocyte contractile dysfunction with cardioplegic arrest and reperfusion.
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Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability
William M. Yarbrough,Rupak Mukherjee,G. Patricia Escobar,Joseph T. Mingoia,Jeffrey A. Sample,Jennifer W. Hendrick,Kathryn B. Dowdy,Julie E. McLean,Robert E. Stroud,Francis G. Spinale +9 more
TL;DR: Modulation of Na(+)/H(+) exchanger activity in the setting of prolonged ischemia and reperfusion may hold therapeutic potential as assessed by absolute infarct size and myocyte-specific enzyme release.
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Biomarkers and heart disease: what is translational success?
Francis G. Spinale,Craig Stolen +1 more
TL;DR: The current potential of protein and small nucleotide (i.e., microRNA) biomarkers are examined in different clinical contexts of heart disease and several of the papers presented in this featured issue of JCTR highlight promising multimarker approaches are highlighted.
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Use of a combined right ventricular ejection fraction-oximetry catheter system for coronary bypass surgery.
TL;DR: The combined catheter system provides the means to monitor both mixed venous oxygen saturation and right ventricular ejection fraction and these data provide a reliable and detailed assessment of cardiopulmonary function that should prove beneficial in the critical care setting.
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Right ventricular pump dysfunction with acute experimental septic shock.
TL;DR: The results suggest that severe RV pump dysfunction occurs early in acute septic shock, manifested by significant reductions in RV ejection fraction and increased in stroke work.